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Literature DB >> 11254646

Evidence of involvement of the mannose receptor in adhesion of Borrelia burgdorferi to monocyte/macrophages.

M Cinco¹, B Cini, R Murgia, G Presani, M Prodan, S Perticarari.

Abstract

The mannose receptor (MR) plays an important role in the recognition of some pathogens in nonopsonic phagocytosis and in antigen presentation to T cells. We found that Borrelia burgdorferi, the agent of Lyme borreliosis, adheres to monocyte-derived macrophages and to rat MR-transfected cells but not to untransfected cells. Antibodies to MR and sugars such as mannose, mannan, fucose, and some lectins significantly lowered the adhesion, confirming participation of the MR in the binding.

Entities: Chemical Disease Species

Mesh：

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Year: 2001 PMID： 11254646 PMCID： PMC98218 DOI： 10.1128/IAI.69.4.2743-2747.2001

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

27 in total

Review 1. Macrophage lectins in host defence.

Authors: S A Linehan; L Martínez-Pomares; S Gordon
Journal: Microbes Infect Date: 2000-03 Impact factor: 2.700

2. Lipoproteins from Borrelia burgdorferi applied in liposomes and presented by dendritic cells induce CD8(+) T-lymphocytes in vitro.

Authors: C Beermann; H Wunderli-Allenspach; P Groscurth; L Filgueira
Journal: Cell Immunol Date: 2000-05-01 Impact factor: 4.868

3. The mannose receptor functions as a high capacity and broad specificity antigen receptor in human dendritic cells.

Authors: A J Engering; M Cella; D Fluitsma; M Brockhaus; E C Hoefsmit; A Lanzavecchia; J Pieters
Journal: Eur J Immunol Date: 1997-09 Impact factor: 5.532

4. Integrins alpha(v)beta3 and alpha5beta1 mediate attachment of lyme disease spirochetes to human cells.

Authors: J Coburn; L Magoun; S C Bodary; J M Leong
Journal: Infect Immun Date: 1998-05 Impact factor: 3.441

5. The lipid component of lipoproteins from Borrelia burgdorferi: structural analysis, antigenicity, and presentation via human dendritic cells.

Authors: C Beermann; G Lochnit; R Geyer; P Groscurth; L Filgueira
Journal: Biochem Biophys Res Commun Date: 2000-01-27 Impact factor: 3.575

6. Interaction with Borrelia burgdorferi causes increased expression of the CR3 integrin and increased binding affinity to fibronectin via CR3.

Authors: M Cinco; E Panfili; G Presani; S Perticarari
Journal: J Mol Microbiol Biotechnol Date: 2000-10

7. Surface receptors of neutrophils towards B. burgdorferi.

Authors: M Cinco; R Murgia; S Perticarari; G Presani
Journal: Wien Klin Wochenschr Date: 1998-12-23 Impact factor: 1.704

8. Identification of a 47 kDa fibronectin-binding protein expressed by Borrelia burgdorferi isolate B31.

Authors: W S Probert; B J Johnson
Journal: Mol Microbiol Date: 1998-12 Impact factor: 3.501

9. Human dendritic cells phagocytose and process Borrelia burgdorferi.

Authors: L Filgueira; F O Nestlé; M Rittig; H I Joller; P Groscurth
Journal: J Immunol Date: 1996-10-01 Impact factor: 5.422

10. Human epidermal Langerhans cells express the mannose-fucose binding receptor.

Authors: B Condaminet; J Péguet-Navarro; P D Stahl; C Dalbiez-Gauthier; D Schmitt; O Berthier-Vergnes
Journal: Eur J Immunol Date: 1998-11 Impact factor: 5.532

9 in total

1. Borrelia burgdorferi organisms lacking plasmids 25 and 28-1 are internalized by human blood phagocytes at a rate identical to that of the wild-type strain.

Authors: Samiya Al-Robaiy; Jens Knauer; Reinhard K Straubinger
Journal: Infect Immun Date: 2005-09 Impact factor: 3.441

Evidence of involvement of the mannose receptor in adhesion of Borrelia burgdorferi to monocyte/macrophages.

Review 1. Macrophage lectins in host defence.

2. Lipoproteins from Borrelia burgdorferi applied in liposomes and presented by dendritic cells induce CD8(+) T-lymphocytes in vitro.

3. The mannose receptor functions as a high capacity and broad specificity antigen receptor in human dendritic cells.

4. Integrins alpha(v)beta3 and alpha5beta1 mediate attachment of lyme disease spirochetes to human cells.

5. The lipid component of lipoproteins from Borrelia burgdorferi: structural analysis, antigenicity, and presentation via human dendritic cells.

6. Interaction with Borrelia burgdorferi causes increased expression of the CR3 integrin and increased binding affinity to fibronectin via CR3.

7. Surface receptors of neutrophils towards B. burgdorferi.

8. Identification of a 47 kDa fibronectin-binding protein expressed by Borrelia burgdorferi isolate B31.

9. Human dendritic cells phagocytose and process Borrelia burgdorferi.

10. Human epidermal Langerhans cells express the mannose-fucose binding receptor.

1. Borrelia burgdorferi organisms lacking plasmids 25 and 28-1 are internalized by human blood phagocytes at a rate identical to that of the wild-type strain.

2. Phagocytic Receptors Activate Syk and Src Signaling during Borrelia burgdorferi Phagocytosis.

Review 3. Lyme arthritis: current concepts and a change in paradigm.

4. Exposed and hidden lectin-binding epitopes at the surface of Borrelia burgdorferi.

5. Analysis of Borrelia burgdorferi Surface Proteins as Determinants in Establishing Host Cell Interactions.

6. Stage-specific sampling by pattern recognition receptors during Candida albicans phagocytosis.

Review 7. Phagosomal TLR signaling upon Borrelia burgdorferi infection.

Review 8. A bite so sweet: the glycobiology interface of tick-host-pathogen interactions.

Review 9. A joint effort: The interplay between the innate and the adaptive immune system in Lyme arthritis.