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Literature DB >> 11254643

Generation and characterization of a defined mutant of Streptococcus suis lacking suilysin.

A G Allen¹, S Bolitho, H Lindsay, S Khan, C Bryant, P Norton, P Ward, J Leigh, J Morgan, H Riches, S Eastty, D Maskell.

Abstract

A defined allelic-replacement mutant of the sly gene, encoding a thiol-activated cytolysin, from a European isolate of Streptococcus suis serotype 2 was generated and characterized. Unlike the parental strain, it is nonhemolytic, noncytotoxic for cultured macrophage-like cells, avirulent in a mouse infection model, yet only slightly attenuated in a porcine model of systemic infection.

Entities: Chemical Disease Species

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Year: 2001 PMID： 11254643 PMCID： PMC98215 DOI： 10.1128/IAI.69.4.2732-2735.2001

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

12 in total

1. The nature of cell wall-derived inflammatory components of pneumococci.

Authors: A Tomasz; K Saukkonen
Journal: Pediatr Infect Dis J Date: 1989-12 Impact factor: 2.129

2. Streptococcus suis serotype 2 interactions with human brain microvascular endothelial cells.

Authors: N Charland; V Nizet; C E Rubens; K S Kim; S Lacouture; M Gottschalk
Journal: Infect Immun Date: 2000-02 Impact factor: 3.441

3. Heat-killed Streptococcus suis capsular type 2 strains stimulate tumor necrosis factor alpha and interleukin-6 production by murine macrophages.

Authors: M Segura; J Stankova; M Gottschalk
Journal: Infect Immun Date: 1999-09 Impact factor: 3.441

4. Protection of experimentally infected pigs by suilysin, the thiol-activated haemolysin of Streptococcus suis.

Authors: A A Jacobs; A J van den Berg; P L Loeffen
Journal: Vet Rec Date: 1996-09-07 Impact factor: 2.695

5. Production of suilysin, the thiol-activated haemolysin of Streptococcus suis, by field isolates from diseased pigs.

Authors: A A Jacobs; A J van den Berg; J C Baars; B Nielsen; L W Johannsen
Journal: Vet Rec Date: 1995-09-16 Impact factor: 2.695

6. Epithelial invasion and cell lysis by virulent strains of Streptococcus suis is enhanced by the presence of suilysin.

Authors: P M Norton; C Rolph; P N Ward; R W Bentley; J A Leigh
Journal: FEMS Immunol Med Microbiol Date: 1999-10

7. The relative role of bacterial cell wall and capsule in the induction of inflammation in pneumococcal meningitis.

Authors: E Tuomanen; A Tomasz; B Hengstler; O Zak
Journal: J Infect Dis Date: 1985-03 Impact factor: 5.226

8. Characterization of Streptococcus suis capsular type 2 haemolysin.

Authors: M G Gottschalk; S Lacouture; J D Dubreuil
Journal: Microbiology Date: 1995-01 Impact factor: 2.777

9. Partial characterization of Streptococcus suis type 2 hemolysin.

Authors: I Feder; M M Chengappa; B Fenwick; M Rider; J Staats
Journal: J Clin Microbiol Date: 1994-05 Impact factor: 5.948

10. The limited role of pneumolysin in the pathogenesis of pneumococcal meningitis.

Authors: I R Friedland; M M Paris; S Hickey; S Shelton; K Olsen; J C Paton; G H McCracken
Journal: J Infect Dis Date: 1995-09 Impact factor: 5.226

35 in total

1. Role of capsule and suilysin in mucosal infection of complement-deficient mice with Streptococcus suis.

Authors: Maren Seitz; Andreas Beineke; Alena Singpiel; Jörg Willenborg; Pavel Dutow; Ralph Goethe; Peter Valentin-Weigand; Andreas Klos; Christoph G Baums
Journal: Infect Immun Date: 2014-03-31 Impact factor: 3.441

2. Viral Coinfection Replaces Effects of Suilysin on Streptococcus suis Adherence to and Invasion of Respiratory Epithelial Cells Grown under Air-Liquid Interface Conditions.

Authors: Georg Herrler; Nai-Huei Wu; Peter Valentin-Weigand; Fandan Meng; Jie Tong; Désirée Vötsch; Ju-Yi Peng; Xuehui Cai; Maren Willenborg
Journal: Infect Immun Date: 2019-07-23 Impact factor: 3.441

3. Differentiation of highly virulent strains of Streptococcus suis serotype 2 according to glutamate dehydrogenase electrophoretic and sequence type.

Authors: Russell Kutz; Ogi Okwumabua
Journal: J Clin Microbiol Date: 2008-08-06 Impact factor: 5.948

4. Characterization and proteome analysis of inosine 5-monophosphate dehydrogenase in epidemic Streptococcus suis serotype 2.

Authors: Junming Zhou; Xuehan Zhang; Kongwang He; Wei Wang; Yanxiu Ni; Haodan Zhu; Zhengyu Yu; Aihua Mao; Lixin Lv
Journal: Curr Microbiol Date: 2014-01-24 Impact factor: 2.188

5. Identification of a novel virulence determinant with serum opacification activity in Streptococcus suis.

Authors: Christoph G Baums; Ute Kaim; Marcus Fulde; Girish Ramachandran; Ralph Goethe; Peter Valentin-Weigand
Journal: Infect Immun Date: 2006-11 Impact factor: 3.441

6. Contribution of fibronectin-binding protein to pathogenesis of Streptococcus suis serotype 2.

Authors: Astrid de Greeff; Herma Buys; Robin Verhaar; Janny Dijkstra; Loek van Alphen; Hilde E Smith
Journal: Infect Immun Date: 2002-03 Impact factor: 3.441

7. The β-galactosidase (BgaC) of the zoonotic pathogen Streptococcus suis is a surface protein without the involvement of bacterial virulence.

Authors: Dan Hu; Fengyu Zhang; Huimin Zhang; Lina Hao; Xiufang Gong; Meiling Geng; Min Cao; Feng Zheng; Jin Zhu; Xiuzhen Pan; Jiaqi Tang; Youjun Feng; Changjun Wang
Journal: Sci Rep Date: 2014-02-21 Impact factor: 4.379