Literature DB >> 11253650

Capitalizing on large-scale mouse mutagenesis screens.

M J Justice1.   

Abstract

Variation is the crux of genetics. Mutagenesis screens in organisms from bacteria to fish have provided a battery of mutants that define protein functions within complex pathways. Large-scale mutation isolation has been carried out in Caenorhabditis elegans, Drosophila melanogaster and zebrafish, and has been recently reported in the mouse in two screens that have generated many new, clinically relevant mutations to reveal the power of phenotype-driven screens in a mammal.

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Mesh：

Year:  2000        PMID： 11253650     DOI： 10.1038/35038549

Source DB:  PubMed          Journal:  Nat Rev Genet        ISSN： 1471-0056            Impact factor:   53.242


  26 in total

1.  Discovery Genetics - The History and Future of Spontaneous Mutation Research.

Authors:  Muriel T Davisson; David E Bergstrom; Laura G Reinholdt; Leah Rae Donahue
Journal:  Curr Protoc Mouse Biol       Date:  2012-06-01

2.  Phenotypic and genetic analysis of the cerebellar mutant tmgc26, a new ENU-induced ROR-alpha allele.

Authors:  Douglas J Swanson; Ekaterina Y Steshina; Paul Wakenight; Kimberly A Aldinger; Dan Goldowitz; Kathleen J Millen; Victor V Chizhikov
Journal:  Eur J Neurosci       Date:  2010-08-16       Impact factor: 3.386

3.  Identification of mutations from phenotype-driven ENU mutagenesis in mouse chromosome 7.

Authors:  Cymbeline T Culiat; Mitchell L Klebig; Zhaowei Liu; Heidi Monroe; Beverly Stanford; Jayashree Desai; Samvit Tandan; Lori Hughes; Marilyn K Kerley; Donald A Carpenter; Dabney K Johnson; Eugene M Rinchik; Qingbo Li
Journal:  Mamm Genome       Date:  2005-08       Impact factor: 2.957

Review 4.  Metabolic syndrome components in murine models.

Authors:  Heather A Lawson; James M Cheverud
Journal:  Endocr Metab Immune Disord Drug Targets       Date:  2010-03       Impact factor: 2.895

5.  Genetics of dark skin in mice.

Authors:  Karen R Fitch; Kelly A McGowan; Catherine D van Raamsdonk; Helmut Fuchs; Daekee Lee; Anne Puech; Yann Hérault; David W Threadgill; Martin Hrabé de Angelis; Gregory S Barsh
Journal:  Genes Dev       Date:  2003-01-15       Impact factor: 11.361

6.  Interactions between Twist and other core epithelial-mesenchymal transition factors are controlled by GSK3-mediated phosphorylation.

Authors:  Rachel Lander; Talia Nasr; Stacy D Ochoa; Kara Nordin; Maneeshi S Prasad; Carole Labonne
Journal:  Nat Commun       Date:  2013       Impact factor: 14.919

7.  Mouse limb deformity mutations disrupt a global control region within the large regulatory landscape required for Gremlin expression.

Authors:  Aimée Zuniga; Odyssé Michos; François Spitz; Anna-Pavlina G Haramis; Lia Panman; Antonella Galli; Kristina Vintersten; Christian Klasen; William Mansfield; Sylwia Kuc; Denis Duboule; Rosanna Dono; Rolf Zeller
Journal:  Genes Dev       Date:  2004-06-15       Impact factor: 11.361

Review 8.  Moving forward with chemical mutagenesis in the mouse.

Authors:  Timothy P O'Brien; Wayne N Frankel
Journal:  J Physiol       Date:  2004-01-01       Impact factor: 5.182

Review 9.  Next-generation sequencing of vertebrate experimental organisms.

Authors:  Daniel J Turner; Thomas M Keane; Ian Sudbery; David J Adams
Journal:  Mamm Genome       Date:  2009-05-19       Impact factor: 2.957

10.  Discovery of candidate disease genes in ENU-induced mouse mutants by large-scale sequencing, including a splice-site mutation in nucleoredoxin.

Authors:  Melissa K Boles; Bonney M Wilkinson; Laurens G Wilming; Bin Liu; Frank J Probst; Jennifer Harrow; Darren Grafham; Kathryn E Hentges; Lanette P Woodward; Andrea Maxwell; Karen Mitchell; Michael D Risley; Randy Johnson; Karen Hirschi; James R Lupski; Yosuke Funato; Hiroaki Miki; Pablo Marin-Garcia; Lucy Matthews; Alison J Coffey; Anne Parker; Tim J Hubbard; Jane Rogers; Allan Bradley; David J Adams; Monica J Justice
Journal:  PLoS Genet       Date:  2009-12-11       Impact factor: 5.917
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