| Literature DB >> 11253366 |
C Francastel1, D Schübeler, D I Martin, M Groudine.
Abstract
The regulated expression of genes during development and differentiation is influenced by the availability of regulatory proteins and accessibility of the DNA to the transcriptional apparatus. There is growing evidence that the transcriptional activity of genes is influenced by nuclear organization, which itself changes during differentiation. How do these changes in nuclear organization help to establish specific patterns of gene expression?Mesh：
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Year: 2000 PMID： 11253366 DOI： 10.1038/35040083
Source DB: PubMed Journal: Nat Rev Mol Cell Biol ISSN： 1471-0072 Impact factor: 94.444