PURPOSE: To describe genetic epidemiologic aspects of osteoporosis. METHODS: 69 patients with osteoporosis were interviewed regarding personal and family histories of osteoporosis and related fractures. Family history information was obtained on 421 first degree and 748 second degree relatives. RESULTS: 45% of cases reported a family history of osteoporosis. Familial cases were characterized neither by an earlier age of diagnosis nor by a greater degree of phenotypic severity. Empiric risks for osteoporosis were highest for mothers, 33%, and were 19% for sisters. CONCLUSION: These results provide an initial genetic epidemiologic profile for osteoporosis and information useful for genetic counseling.
PURPOSE: To describe genetic epidemiologic aspects of osteoporosis. METHODS: 69 patients with osteoporosis were interviewed regarding personal and family histories of osteoporosis and related fractures. Family history information was obtained on 421 first degree and 748 second degree relatives. RESULTS: 45% of cases reported a family history of osteoporosis. Familial cases were characterized neither by an earlier age of diagnosis nor by a greater degree of phenotypic severity. Empiric risks for osteoporosis were highest for mothers, 33%, and were 19% for sisters. CONCLUSION: These results provide an initial genetic epidemiologic profile for osteoporosis and information useful for genetic counseling.
Authors: M Güler-Yüksel; J Bijsterbosch; Y P M Goekoop-Ruiterman; J K de Vries-Bouwstra; H K Ronday; A J Peeters; J M de Jonge-Bok; F C Breedveld; B A C Dijkmans; C F Allaart; W F Lems Journal: Ann Rheum Dis Date: 2007-04-24 Impact factor: 19.103