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Literature DB >> 11252650

Calcium channel antagonists for the treatment of bipolar disorder.

Abstract

Calcium channel antagonists (CCAs) have many clinical applications, including their possible use in the treatment of bipolar disorder. Two justifications for this last application are some overlap in physiological activities of CCAs with those of lithium, and a possible association between bipolar disorder and calcium dysregulation. While the data from earlier studies support the use of verapamil in treating bipolar mania. more recent better-controlled trials have not. This paper reviews the available body of data regarding CCAs in the treatment of bipolar disorder, concluding there is presently limited support for their efficacy.

Entities: Chemical Disease

Mesh：

Substances：

Year: 2000 PMID： 11252650 DOI： 10.1034/j.1399-5618.2000.020204.x

Source DB: PubMed Journal: Bipolar Disord ISSN： 1398-5647 Impact factor: 6.744

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Cited

17 in total

Review 1. P/Q-type calcium channel modulators.

Authors: V Nimmrich; G Gross
Journal: Br J Pharmacol Date: 2012-10 Impact factor: 8.739

2. Rare variants in neuronal excitability genes influence risk for bipolar disorder.

Authors: Seth A Ament; Szabolcs Szelinger; Gustavo Glusman; Justin Ashworth; Liping Hou; Nirmala Akula; Tatyana Shekhtman; Judith A Badner; Mary E Brunkow; Denise E Mauldin; Anna-Barbara Stittrich; Katherine Rouleau; Sevilla D Detera-Wadleigh; John I Nurnberger; Howard J Edenberg; Elliot S Gershon; Nicholas Schork; Nathan D Price; Richard Gelinas; Leroy Hood; David Craig; Francis J McMahon; John R Kelsoe; Jared C Roach
Journal: Proc Natl Acad Sci U S A Date: 2015-02-17 Impact factor: 11.205

3. Probing the lithium-response pathway in hiPSCs implicates the phosphoregulatory set-point for a cytoskeletal modulator in bipolar pathogenesis.

Authors: Brian T D Tobe; Andrew M Crain; Alicia M Winquist; Barbara Calabrese; Hiroko Makihara; Wen-Ning Zhao; Jasmin Lalonde; Haruko Nakamura; Glenn Konopaske; Michelle Sidor; Cameron D Pernia; Naoya Yamashita; Moyuka Wada; Yuuka Inoue; Fumio Nakamura; Steven D Sheridan; Ryan W Logan; Michael Brandel; Dongmei Wu; Joshua Hunsberger; Laurel Dorsett; Cordulla Duerr; Ranor C B Basa; Michael J McCarthy; Namrata D Udeshi; Philipp Mertins; Steven A Carr; Guy A Rouleau; Lina Mastrangelo; Jianxue Li; Gustavo J Gutierrez; Laurence M Brill; Nikolaos Venizelos; Guang Chen; Jeffrey S Nye; Husseini Manji; Jeffrey H Price; Colleen A McClung; Hagop S Akiskal; Martin Alda; De-Maw M Chuang; Joseph T Coyle; Yang Liu; Yang D Teng; Toshio Ohshima; Katsuhiko Mikoshiba; Richard L Sidman; Shelley Halpain; Stephen J Haggarty; Yoshio Goshima; Evan Y Snyder
Journal: Proc Natl Acad Sci U S A Date: 2017-05-12 Impact factor: 11.205

Review 4. CACNA1C (Cav1.2) in the pathophysiology of psychiatric disease.

Authors: Shambhu Bhat; David T Dao; Chantelle E Terrillion; Michal Arad; Robert J Smith; Nikolai M Soldatov; Todd D Gould
Journal: Prog Neurobiol Date: 2012-06-15 Impact factor: 11.685

5. Verapamil augmentation of lithium treatment improves outcome in mania unresponsive to lithium alone: preliminary findings and a discussion of therapeutic mechanisms.

Authors: Alan G Mallinger; Michael E Thase; Roger Haskett; Joan Buttenfield; David A Luckenbaugh; Ellen Frank; David J Kupfer; Husseini K Manji
Journal: Bipolar Disord Date: 2008-12 Impact factor: 6.744

6. Whole-genome association study of bipolar disorder.

Authors: P Sklar; J W Smoller; J Fan; M A R Ferreira; R H Perlis; K Chambert; V L Nimgaonkar; M B McQueen; S V Faraone; A Kirby; P I W de Bakker; M N Ogdie; M E Thase; G S Sachs; K Todd-Brown; S B Gabriel; C Sougnez; C Gates; B Blumenstiel; M Defelice; K G Ardlie; J Franklin; W J Muir; K A McGhee; D J MacIntyre; A McLean; M VanBeck; A McQuillin; N J Bass; M Robinson; J Lawrence; A Anjorin; D Curtis; E M Scolnick; M J Daly; D H Blackwood; H M Gurling; S M Purcell
Journal: Mol Psychiatry Date: 2008-03-04 Impact factor: 15.992

10. A rare mutation of CACNA1C in a patient with bipolar disorder, and decreased gene expression associated with a bipolar-associated common SNP of CACNA1C in brain.

Authors: E S Gershon; K Grennan; J Busnello; J A Badner; F Ovsiew; S Memon; N Alliey-Rodriguez; J Cooper; B Romanos; C Liu
Journal: Mol Psychiatry Date: 2013-08-27 Impact factor: 15.992