Literature DB >> 11251877

Immunomodulation using bacterial enterotoxins.

C P Simmons1, M Ghaem-Magami, L Petrovska, L Lopes, B M Chain, N A Williams, G Dougan.   

Abstract

Immunologic unresponsiveness (tolerance) is a key feature of the mucosal immune system, and deliberate vaccination by a mucosal route can effectively induce immune suppression. However, some bacterial-derived proteins, e.g. cholera toxin and the heat labile toxin of Escherichia coli, are immunogenic and immunomodulatory at mucosal surfaces and can effectively adjuvant immune responses to codelivered bystander antigens. This review summarizes some of the structural and biological characteristics of these toxins and provides examples of how these properties have been exploited for tolerance induction and mucosal vaccine development.

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Year:  2001        PMID： 11251877     DOI： 10.1046/j.1365-3083.2001.00884.x

Source DB:  PubMed          Journal:  Scand J Immunol        ISSN： 0300-9475            Impact factor:   3.487


  17 in total

Review 1.  Mucosal immunity: overcoming the barrier for induction of proximal responses.

Authors:  Brent S McKenzie; Jamie L Brady; Andrew M Lew
Journal:  Immunol Res       Date:  2004       Impact factor: 2.829

2.  Cholera toxin induces a transient depletion of CD8+ intraepithelial lymphocytes in the rat small intestine as detected by microarray and immunohistochemistry.

Authors:  Carl-Fredrik Flach; Stefan Lange; Eva Jennische; Ivar Lönnroth; Jan Holmgren
Journal:  Infect Immun       Date:  2005-09       Impact factor: 3.441

3.  Intimin-specific immune responses prevent bacterial colonization by the attaching-effacing pathogen Citrobacter rodentium.

Authors:  M Ghaem-Maghami; C P Simmons; S Daniell; M Pizza; D Lewis; G Frankel; G Dougan
Journal:  Infect Immun       Date:  2001-09       Impact factor: 3.441

4.  Cholera toxin impairs the differentiation of monocytes into dendritic cells, inducing professional antigen-presenting myeloid cells.

Authors:  Filippo Veglia; Ester Sciaraffia; Antonella Riccomi; Dora Pinto; Donatella R M Negri; Maria Teresa De Magistris; Silvia Vendetti
Journal:  Infect Immun       Date:  2010-12-13       Impact factor: 3.441

5.  Evaluation of a novel Vi conjugate vaccine in a murine model of salmonellosis.

Authors:  Christine Hale; Frances Bowe; Derek Pickard; Simon Clare; Jean-Francois Haeuw; Ultan Powers; Nathalie Menager; Pietro Mastroeni; Gordon Dougan
Journal:  Vaccine       Date:  2006-03-20       Impact factor: 3.641

6.  Functional diversity of heat-labile toxins (LT) produced by enterotoxigenic Escherichia coli: differential enzymatic and immunological activities of LT1 (hLT) AND LT4 (pLT).

Authors:  Juliana F Rodrigues; Camila Mathias-Santos; Maria Elisabete Sbrogio-Almeida; Jaime H Amorim; Joaquim Cabrera-Crespo; Andrea Balan; Luís C S Ferreira
Journal:  J Biol Chem       Date:  2010-12-06       Impact factor: 5.157

7.  Toll-like receptor 2 mediates cellular activation by the B subunits of type II heat-labile enterotoxins.

Authors:  George Hajishengallis; Richard I Tapping; Michael H Martin; Hesham Nawar; Elizabeth A Lyle; Michael W Russell; Terry D Connell
Journal:  Infect Immun       Date:  2005-03       Impact factor: 3.441

8.  Distinctive immunomodulatory and inflammatory properties of the Escherichia coli type II heat-labile enterotoxin LT-IIa and its B pentamer following intradermal administration.

Authors:  Camila Mathias-Santos; Juliana F Rodrigues; Maria Elisabete Sbrogio-Almeida; Terry D Connell; Luís C S Ferreira
Journal:  Clin Vaccine Immunol       Date:  2011-06-15

9.  In vivo and in vitro adjuvant activities of the B subunit of Type IIb heat-labile enterotoxin (LT-IIb-B5) from Escherichia coli.

Authors:  Shuang Liang; Kavita B Hosur; Hesham F Nawar; Michael W Russell; Terry D Connell; George Hajishengallis
Journal:  Vaccine       Date:  2009-05-29       Impact factor: 3.641

10.  Cholera toxin, E. coli heat-labile toxin, and non-toxic derivatives induce dendritic cell migration into the follicle-associated epithelium of Peyer's patches.

Authors:  N G Anosova; S Chabot; V Shreedhar; J A Borawski; B L Dickinson; M R Neutra
Journal:  Mucosal Immunol       Date:  2008-01       Impact factor: 7.313
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