AIMS: The age-specific prevalence of diabetes mellitus and impaired glucose tolerance (IGT) was estimated in 60-year-old individuals in 1996/97 and compared to the prevalence in 1974/75. The study also examined whether or not the change in prevalence of diabetes and IGT could be explained by changes in body mass index (BMI) and physical activity. METHODS: Diabetes and IGT were diagnosed by a standardized oral glucose tolerance test (OGTT) in two Danish population-based, age-specific, birth cohorts. RESULTS: The prevalence of diabetes in 1996/97 was 12.3% among 60-year-old men and 6.8% among women, representing an increase in diabetes of 58% in men and 21% in women compared to 1974/75. The prevalence of IGT was 15.9% among men and 13.1% among women, representing increases of 109 and 16%, respectively. A concurrent increase in BMI in the 22-year period between the two studies explained the increase found in the prevalence of diabetes and IGT. CONCLUSIONS: A marked increase in the prevalence of diabetes and IGT among 60-year-old individuals over a 22-year period was observed - especially in men. The increase was fully explained by a concurrent increase in BMI.
AIMS: The age-specific prevalence of diabetes mellitus and impaired glucose tolerance (IGT) was estimated in 60-year-old individuals in 1996/97 and compared to the prevalence in 1974/75. The study also examined whether or not the change in prevalence of diabetes and IGT could be explained by changes in body mass index (BMI) and physical activity. METHODS:Diabetes and IGT were diagnosed by a standardized oral glucose tolerance test (OGTT) in two Danish population-based, age-specific, birth cohorts. RESULTS: The prevalence of diabetes in 1996/97 was 12.3% among 60-year-old men and 6.8% among women, representing an increase in diabetes of 58% in men and 21% in women compared to 1974/75. The prevalence of IGT was 15.9% among men and 13.1% among women, representing increases of 109 and 16%, respectively. A concurrent increase in BMI in the 22-year period between the two studies explained the increase found in the prevalence of diabetes and IGT. CONCLUSIONS: A marked increase in the prevalence of diabetes and IGT among 60-year-old individuals over a 22-year period was observed - especially in men. The increase was fully explained by a concurrent increase in BMI.
Authors: Erwin Reiling; Jana V van Vliet-Ostaptchouk; Esther van 't Riet; Timon W van Haeften; Pascal A Arp; Torben Hansen; Dennis Kremer; Marlous J Groenewoud; Els C van Hove; Johannes A Romijn; Jan W A Smit; Giel Nijpels; Robert J Heine; André G Uitterlinden; Oluf Pedersen; P Eline Slagboom; Johannes A Maassen; Marten H Hofker; Leen M 't Hart; Jacqueline M Dekker Journal: Eur J Hum Genet Date: 2009-02-11 Impact factor: 4.246
Authors: Anni Brit Sternhagen Nielsen; Volkert Siersma; Svend Kreiner; Line Conradsen Hiort; Thomas Drivsholm; Lene Falgaard Eplov; Hanne Hollnagel Journal: Scand J Prim Health Care Date: 2009 Impact factor: 2.581
Authors: G Andersen; L Wegner; K Yanagisawa; C S Rose; J Lin; C Glümer; T Drivsholm; K Borch-Johnsen; T Jørgensen; T Hansen; B M Spiegelman; O Pedersen Journal: J Med Genet Date: 2005-05 Impact factor: 6.318
Authors: A Johansen; E-M D Nielsen; G Andersen; Y H Hamid; D P Jensen; C Glümer; T Drivsholm; K Borch-Johnsen; T Jørgensen; T Hansen; O Pedersen Journal: Diabetologia Date: 2004-07-17 Impact factor: 10.122
Authors: E Reiling; B Jafar-Mohammadi; E van 't Riet; M N Weedon; J V van Vliet-Ostaptchouk; T Hansen; R Saxena; T W van Haeften; P A Arp; S Das; G Nijpels; M J Groenewoud; E C van Hove; A G Uitterlinden; J W A Smit; A D Morris; A S F Doney; C N A Palmer; C Guiducci; A T Hattersley; T M Frayling; O Pedersen; P E Slagboom; D M Altshuler; L Groop; J A Romijn; J A Maassen; M H Hofker; J M Dekker; M I McCarthy; L M 't Hart Journal: Diabetologia Date: 2009-10-22 Impact factor: 10.122