OBJECTIVE: To determine the expression of CD34 (to evaluate vascularity) and Ki-67 (as a proliferative index) in a variety of phaeochromocytomas and thus assess the utility of these markers as possible predictors of malignancy. PATIENTS AND METHODS: Deparaffinized tissue sections from 21 patients with benign and four with malignant phaeochromocytoma were assessed immunohistochemically to evaluate microvascular counts (using CD34 antigen) and the proliferative index (Ki-67 antigen, monoclonal antibody MIB-1). RESULTS: There was no statistical association between high microvascular counts and malignancy, but there was between the MIB-1 score and malignancy (P < 0.001). CONCLUSIONS: A high MIB-1 score in phaeochromocytoma suggests malignant behaviour in the component cells. The MIB-1 score may be a useful indicator for diagnosing malignant phaeochromocytoma.
OBJECTIVE: To determine the expression of CD34 (to evaluate vascularity) and Ki-67 (as a proliferative index) in a variety of phaeochromocytomas and thus assess the utility of these markers as possible predictors of malignancy. PATIENTS AND METHODS: Deparaffinized tissue sections from 21 patients with benign and four with malignant phaeochromocytoma were assessed immunohistochemically to evaluate microvascular counts (using CD34 antigen) and the proliferative index (Ki-67 antigen, monoclonal antibody MIB-1). RESULTS: There was no statistical association between high microvascular counts and malignancy, but there was between the MIB-1 score and malignancy (P < 0.001). CONCLUSIONS: A high MIB-1 score in phaeochromocytoma suggests malignant behaviour in the component cells. The MIB-1 score may be a useful indicator for diagnosing malignant phaeochromocytoma.
Authors: Hilde Dannenberg; Paul Komminoth; Winand N M Dinjens; Ernst Jan M Speel; Ronald R de Krijger Journal: Endocr Pathol Date: 2003 Impact factor: 3.943
Authors: Patrick P G M Rooijens; Ronald R de Krijger; H Jaap Bonjer; Frieda van der Ham; Alex L Nigg; Hajo A Bruining; Steven W J Lamberts; Erwin van der Harst Journal: Endocr Pathol Date: 2004 Impact factor: 3.943
Authors: Lindsey Oudijk; Francien van Nederveen; Cécile Badoual; Frédérique Tissier; Arthur S Tischler; Marcel Smid; José Gaal; Charlotte Lepoutre-Lussey; Anne-Paule Gimenez-Roqueplo; Winand N M Dinjens; Esther Korpershoek; Ronald de Krijger; Judith Favier Journal: PLoS One Date: 2015-03-20 Impact factor: 3.240