BACKGROUND AND OBJECTIVES: [corrected] For decades, hypotensive anesthesia has been used in an attempt to reduce intraoperative blood loss. Hypotensive epidural anesthesia (HEA) is a relatively new technique in hypotensive anesthesia. Use of a tourniquet has been shown to be associated with a higher risk of cardiovascular and thromboembolic complications. The effect of HEA on blood loss and need for transfusion in total knee replacement (TKR) is not known. METHODS:Thirty consecutive patients scheduled for TKR were randomized to HEA without tourniquet or spinal anesthesia with the use of a tourniquet (SPI). HEA was performed as an epidurally induced sympathetic block and there was an infusion of low-dose epinephrine to stabilize the circulation. RESULTS:Intraoperative mean arterial blood pressure was 48 mm Hg (HEA) versus 83 mm Hg (SPI) (P <.001). Intraoperative blood loss was 146 mL (HEA) versus 13 mL (SPI) (P <.001). Postoperative blood loss at any time was significantly reduced in the HEA group, and total loss of blood was 1,056 mL (HEA) versus 1,826 mL (SPI) (P <.001). Half of the bleeding took place during the first 3 postoperative hours and 80% during the first 24 hours. In the HEA group, 57% of the patients went through surgery and the hospital stay without receiving blood transfusion versus 19% in the SPI group (P <.05). There was a significantly reduced amount of blood transfusion in the HEA group (193 mL) versus 775 mL in the SPI group (P <.005). No cardiopulmonary, cerebral, or renal complications were registered. CONCLUSIONS: We conclude that HEA is a safe technique that allows TKR without a tourniquet. Compared with spinal anesthesia, the use of HEA for TKR significantly reduces blood loss and the need for blood transfusion.
RCT Entities:
BACKGROUND AND OBJECTIVES: [corrected] For decades, hypotensive anesthesia has been used in an attempt to reduce intraoperative blood loss. Hypotensive epidural anesthesia (HEA) is a relatively new technique in hypotensive anesthesia. Use of a tourniquet has been shown to be associated with a higher risk of cardiovascular and thromboembolic complications. The effect of HEA on blood loss and need for transfusion in total knee replacement (TKR) is not known. METHODS: Thirty consecutive patients scheduled for TKR were randomized to HEA without tourniquet or spinal anesthesia with the use of a tourniquet (SPI). HEA was performed as an epidurally induced sympathetic block and there was an infusion of low-dose epinephrine to stabilize the circulation. RESULTS: Intraoperative mean arterial blood pressure was 48 mm Hg (HEA) versus 83 mm Hg (SPI) (P <.001). Intraoperative blood loss was 146 mL (HEA) versus 13 mL (SPI) (P <.001). Postoperative blood loss at any time was significantly reduced in the HEA group, and total loss of blood was 1,056 mL (HEA) versus 1,826 mL (SPI) (P <.001). Half of the bleeding took place during the first 3 postoperative hours and 80% during the first 24 hours. In the HEA group, 57% of the patients went through surgery and the hospital stay without receiving blood transfusion versus 19% in the SPI group (P <.05). There was a significantly reduced amount of blood transfusion in the HEA group (193 mL) versus 775 mL in the SPI group (P <.005). No cardiopulmonary, cerebral, or renal complications were registered. CONCLUSIONS: We conclude that HEA is a safe technique that allows TKR without a tourniquet. Compared with spinal anesthesia, the use of HEA for TKR significantly reduces blood loss and the need for blood transfusion.