Literature DB >> 11250985

Serious adverse events experienced by patients with chronic heart failure taking spironolactone.

C Berry1, J J McMurray.   

Abstract

In patients with chronic heart failure, spironolactone added to conventional treatment may lead to serious and, occasionally, fatal hyperkalaemia. In some cases this seems to happen because spironolactone causes diarrhoea. Four cases involving men with New York Heart Association functional class III heart failure are presented. As these cases revealed, close monitoring of blood chemistry is mandatory after starting spironolactone, and patients should be advised to stop spironolactone immediately if diarrhoea develops.

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Year:  2001        PMID： 11250985      PMCID： PMC1729677          DOI： 10.1136/heart.85.4.e8

Source DB:  PubMed          Journal:  Heart        ISSN： 1355-6037            Impact factor:   5.994


  3 in total

1.  Consequences of fluid loss in patients treated with ACE inhibitors.

Authors:  J McMurray; D M Matthews
Journal:  Postgrad Med J       Date:  1987-05       Impact factor: 2.401

2.  Hyperkalemia and hyporeninemic hypoaldosteronism.

Authors:  R A DeFronzo
Journal:  Kidney Int       Date:  1980-01       Impact factor: 10.612

3.  The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators.

Authors:  B Pitt; F Zannad; W J Remme; R Cody; A Castaigne; A Perez; J Palensky; J Wittes
Journal:  N Engl J Med       Date:  1999-09-02       Impact factor: 91.245
  3 in total
  9 in total

1.  Nephrotoxicity in the elderly due to co-prescription of ACE inhibitors and NSAIDs.

Authors:  O M Jolobe
Journal:  J R Soc Med       Date:  2001-12       Impact factor: 5.344

2.  Interaction of spironolactone with ACE inhibitors or angiotensin receptor blockers: analysis of 44 cases.

Authors:  Eike Wrenger; Regina Müller; Michael Moesenthin; Tobias Welte; Jürgen C Frölich; Klaus H Neumann
Journal:  BMJ       Date:  2003-07-19

3.  Tolerability of spironolactone in patients with chronic heart failure -- a cautionary message.

Authors:  Miles D Witham; Neil D Gillespie; Allan D Struthers
Journal:  Br J Clin Pharmacol       Date:  2004-11       Impact factor: 4.335

4.  Effects of low-dose spironolactone combined with irbesartan on cardiac hypertrophy induced by pressure overload in rats.

Authors:  Jingtao Ma; Hongxue Zhang; Huicai Guo; Yanfang Xu
Journal:  Am J Transl Res       Date:  2014-11-22       Impact factor: 4.060

5.  Comparative efficacy and safety of mineralocorticoid receptor antagonists in heart failure: a network meta-analysis of randomized controlled trials.

Authors:  Pingping Yang; Wen Shen; Xi Chen; Dan Zhu; Xiuxiu Xu; Tao Wu; Gaosi Xu; Qinghua Wu
Journal:  Heart Fail Rev       Date:  2019-09       Impact factor: 4.214

6.  The Safety of Eplerenone in Hemodialysis Patients: A Noninferiority Randomized Controlled Trial.

Authors:  Michael Walsh; Braden Manns; Amit X Garg; Joe Bueti; Christian Rabbat; Andrew Smyth; Jessica Tyrwhitt; Jackie Bosch; Peggy Gao; P J Devereaux; Ron Wald
Journal:  Clin J Am Soc Nephrol       Date:  2015-07-02       Impact factor: 8.237

7.  Effects of spironolactone on endothelial function, vascular angiotensin converting enzyme activity, and other prognostic markers in patients with mild heart failure already taking optimal treatment.

Authors:  J E Macdonald; N Kennedy; A D Struthers
Journal:  Heart       Date:  2004-07       Impact factor: 5.994

Review 8.  Additional use of an aldosterone antagonist in patients with mild to moderate chronic heart failure: a systematic review and meta-analysis.

Authors:  Li-jun Hu; Yun-qing Chen; Song-bai Deng; Jian-lin Du; Qiang She
Journal:  Br J Clin Pharmacol       Date:  2013-05       Impact factor: 4.335

9.  Mineralocorticoid receptor antagonists for heart failure: a real-life observational study.

Authors:  Noemi Bruno; Gianfranco Sinagra; Stefania Paolillo; Alice Bonomi; Ugo Corrà; Massimo Piepoli; Fabrizio Veglia; Elisabetta Salvioni; Rocco Lagioia; Marco Metra; Giuseppe Limongelli; Gaia Cattadori; Angela B Scardovi; Valentina Carubelli; Domenico Scrutino; Roberto Badagliacca; Marco Guazzi; Rosa Raimondo; Piero Gentile; Damiano Magrì; Michele Correale; Gianfranco Parati; Federica Re; Mariantonietta Cicoira; Maria Frigerio; Maurizio Bussotti; Carlo Vignati; Fabrizio Oliva; Alessandro Mezzani; Giuseppe Vergaro; Andrea Di Lenarda; Claudio Passino; Susanna Sciomer; Giuseppe Pacileo; Roberto Ricci; Mauro Contini; Anna Apostolo; Pietro Palermo; Massimo Mapelli; Cosimo Carriere; Francesco Clemenza; Simone Binno; Romualdo Belardinelli; Carlo Lombardi; Pasquale Perrone Filardi; Michele Emdin; Piergiuseppe Agostoni
Journal:  ESC Heart Fail       Date:  2018-02-04
  9 in total

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