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Literature DB >> 11249718

Edaravone Mitsubishi-Tokyo.

Abstract

Mitsubishi-Tokyo (formerly Mitsubishi Chemical) is developing edaravone (norphenazone), a free radical scavenger, for the potential treatment of cardiovascular disease, cerebrovascular ischemia and cerebral edema. By February 2000, edaravone had been filed in Japan for the treatment of acute brain infarction, and was in phase III trials for subarachnoid hemorrhage [365460]. The compound blocks the action of the lipoperoxide, 15-HPETE, which normally increases with age and may be associated with neurodegeneration.

Entities: Chemical Disease

Mesh：

Substances：

Year: 2000 PMID： 11249718

Source DB: PubMed Journal: Curr Opin Investig Drugs ISSN： 1472-4472

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Cited

12 in total

Review 1. Post-stroke inflammatory response: effects of stroke evolution and outcome.

Authors: Kiat T Tan; Gregory Y H Lip; Andrew D Blann
Journal: Curr Atheroscler Rep Date: 2003-07 Impact factor: 5.113

2. Scavenging free radicals improves endothelial dysfunction in human coronary arteries in vivo.

Authors: Jun-ichi Oyama; Shinji Satoh; Nobuhiro Suematsu; Toshiaki Kadokami; Toyoki Maeda; Masahiro Sugano; Naoki Makino
Journal: Heart Vessels Date: 2010-07-31 Impact factor: 2.037

3. Survivin is involved in the anti-apoptotic effect of edaravone in PC12 cells.

Authors: Xue-Yuan Liu; Ling-Ling Yao; Yu-Juan Chen; Bei-Bei Tao; Yong-Chun Yu; Wei-Hong Bian; Jing Yu; Yong-Gang Wang
Journal: Mol Cell Biochem Date: 2009-02-18 Impact factor: 3.396

Review 4. 1,4-Dihydropyridine Derivatives: Dihydronicotinamide Analogues-Model Compounds Targeting Oxidative Stress.

Authors: Astrida Velena; Neven Zarkovic; Koraljka Gall Troselj; Egils Bisenieks; Aivars Krauze; Janis Poikans; Gunars Duburs
Journal: Oxid Med Cell Longev Date: 2016-01-06 Impact factor: 6.543

5. Edaravone improves spatial memory and modulates endoplasmic reticulum stress-mediated apoptosis after abdominal surgery in mice.

Authors: Ayong Tian; Hong Ma; Rongwei Zhang; Yong Cui; Chengfu Wan
Journal: Exp Ther Med Date: 2017-05-22 Impact factor: 2.447

Edaravone Mitsubishi-Tokyo.

Review 1. Post-stroke inflammatory response: effects of stroke evolution and outcome.

2. Scavenging free radicals improves endothelial dysfunction in human coronary arteries in vivo.

3. Survivin is involved in the anti-apoptotic effect of edaravone in PC12 cells.

Review 4. 1,4-Dihydropyridine Derivatives: Dihydronicotinamide Analogues-Model Compounds Targeting Oxidative Stress.

5. Edaravone improves spatial memory and modulates endoplasmic reticulum stress-mediated apoptosis after abdominal surgery in mice.

6. Fructose-1,6-bisphosphate does not preserve ATP in hypoxic-ischemic neonatal cerebrocortical slices.

7. Renoprotective effect of edaravone in acute limb ischemia/reperfusion injury.

8. Cobalt-Catalyzed Suzuki Biaryl Coupling of Aryl Halides.

9. Therapeutic time window for edaravone treatment of traumatic brain injury in mice.

10. Density functional theory (DFT) study of edaravone derivatives as antioxidants.