Literature DB >> 11249624

Aspects of the transport and delivery of antisense oligonucleotides.

R L Juliano1, H Yoo.   

Abstract

This article will examine recent developments concerning the cellular uptake and subcellular trafficking of antisense oligonucleotides. It will also examine the merits of various delivery strategies for oligonucleotides. The use of conjugates of oligonucleotides with 'cell penetrating peptides' as a promising delivery technology will be emphasized.

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Year:  2000        PMID： 11249624

Source DB:  PubMed          Journal:  Curr Opin Mol Ther        ISSN： 1464-8431


  13 in total

1.  Enhanced delivery of antisense oligonucleotides with fluorophore-conjugated PAMAM dendrimers.

Authors:  H Yoo; R L Juliano
Journal:  Nucleic Acids Res       Date:  2000-11-01       Impact factor: 16.971

2.  Receptor-mediated endocytosis of phosphodiester oligonucleotides in the HepG2 cell line: evidence for non-conventional intracellular trafficking.

Authors:  Philippe de Diesbach; Francisca N'Kuli; Catherine Berens; Etienne Sonveaux; Michel Monsigny; Annie-Claude Roche; Pierre J Courtoy
Journal:  Nucleic Acids Res       Date:  2002-04-01       Impact factor: 16.971

3.  Tat-conjugated PAMAM dendrimers as delivery agents for antisense and siRNA oligonucleotides.

Authors:  Hyunmin Kang; Robert DeLong; Michael H Fisher; Rudolph L Juliano
Journal:  Pharm Res       Date:  2005-10-01       Impact factor: 4.200

4.  Dendritic alpha,epsilon-poly(L-lysine)s as delivery agents for antisense oligonucleotides.

Authors:  Khee Dong Eom; Sun Mi Park; Huu Dung Tran; Myong Soo Kim; Ri Na Yu; Hoon Yoo
Journal:  Pharm Res       Date:  2007-03-21       Impact factor: 4.200

5.  Nanoparticle for delivery of antisense γPNA oligomers targeting CCR5.

Authors:  Raman Bahal; Nicole Ali McNeer; Danith H Ly; W Mark Saltzman; Peter M Glazer
Journal:  Artif DNA PNA XNA       Date:  2013 Apr-Jun

6.  β-Catenin knockdown in liver tumor cells by a cell permeable gamma guanidine-based peptide nucleic acid.

Authors:  Evan Delgado; Raman Bahal; Jing Yang; Jung M Lee; Danith H Ly; Satdarshan P S Monga
Journal:  Curr Cancer Drug Targets       Date:  2013-10       Impact factor: 3.428

7.  Conjugates of antisense oligonucleotides with the Tat and antennapedia cell-penetrating peptides: effects on cellular uptake, binding to target sequences, and biologic actions.

Authors:  Anna Astriab-Fisher; Dimitri Sergueev; Michael Fisher; Barbara Ramsay Shaw; R L Juliano
Journal:  Pharm Res       Date:  2002-06       Impact factor: 4.200

8.  Antitumor effects of EGFR antisense guanidine-based peptide nucleic acids in cancer models.

Authors:  Sufi M Thomas; Bichismita Sahu; Srinivas Rapireddy; Raman Bahal; Sarah E Wheeler; Eva M Procopio; Joseph Kim; Sonali C Joyce; Sarah Contrucci; Yun Wang; Simion I Chiosea; Kira L Lathrop; Simon Watkins; Jennifer R Grandis; Bruce A Armitage; Danith H Ly
Journal:  ACS Chem Biol       Date:  2012-11-09       Impact factor: 5.100

9.  Synthesis of conformationally preorganized and cell-permeable guanidine-based gamma-peptide nucleic acids (gammaGPNAs).

Authors:  Bichismita Sahu; Venugopal Chenna; Kira L Lathrop; Sufi M Thomas; Gerald Zon; Kenneth J Livak; Danith H Ly
Journal:  J Org Chem       Date:  2009-02-20       Impact factor: 4.354

10.  Effect of Steric Constraint at the γ-Backbone Position on the Conformations and Hybridization Properties of PNAs.

Authors:  Matthew J Crawford; Srinivas Rapireddy; Raman Bahal; Iulia Sacui; Danith H Ly
Journal:  J Nucleic Acids       Date:  2011-05-25
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