Literature DB >> 11249506

TNF-alpha antagonists for the treatment of Crohn's disease.

L Y Kam1, S R Targan.   

Abstract

New medical therapies that inhibit the bioactivity of TNF-alpha represent a major breakthrough in the treatment of Crohn's disease (CD). Anti-TNF-alpha, monoclonal, chimeric antibody (infliximab) is now FDA approved for use in patients with active CD. Other investigational drugs that also inhibit TNF-alpha activity include new 'humanised' anti-TNF-alpha antibodies (CDP571), thalidomide, new analogues of thalidomide, and TNF-alpha receptor fusion proteins. This review will summarise the key clinical data for each of these categories of TNF-alpha inhibition and discuss the potential economic impact of these new compounds on the cost of CD management.

Entities:  

Mesh：

Substances：

Year:  2000        PMID： 11249506     DOI： 10.1517/14656566.1.4.615

Source DB:  PubMed          Journal:  Expert Opin Pharmacother        ISSN： 1465-6566            Impact factor:   3.889


  5 in total

1.  Vasoactive intestinal peptide impairs leucocyte migration but fails to modify experimental murine colitis.

Authors:  R Newman; N Cuan; T Hampartzoumian; S J Connor; A R Lloyd; M C Grimm
Journal:  Clin Exp Immunol       Date:  2005-03       Impact factor: 4.330

Review 2.  Histamine H1-receptor antagonists with immunomodulating activities: potential use for modulating T helper type 1 (Th1)/Th2 cytokine imbalance and inflammatory responses in allergic diseases.

Authors:  T Okamoto; S Iwata; K Ohnuma; N H Dang; C Morimoto
Journal:  Clin Exp Immunol       Date:  2009-07       Impact factor: 4.330

3.  Melatonin reduces bacterial translocation and apoptosis in trinitrobenzene sulphonic acid-induced colitis of rats.

Authors:  Alper Akcan; Can Kucuk; Erdogan Sozuer; Duygu Esel; Hizir Akyildiz; Hulya Akgun; Sabahattin Muhtaroglu; Yucel Aritas
Journal:  World J Gastroenterol       Date:  2008-02-14       Impact factor: 5.742

4.  Two High Throughput Screen Assays for Measurement of TNF-α in THP-1 Cells.

Authors:  Kristin P Leister; Ruili Huang; Bonnie L Goodwin; Andrew Chen; Christopher P Austin; Menghang Xia
Journal:  Curr Chem Genomics       Date:  2011-05-10

Review 5.  Inflammatory Bowel Disease: An Overview of Immune Mechanisms and Biological Treatments.

Authors:  Bruno Rafael Ramos de Mattos; Maellin Pereira Gracindo Garcia; Julia Bier Nogueira; Lisiery Negrini Paiatto; Cassia Galdino Albuquerque; Caique Lopes Souza; Luís Gustavo Romani Fernandes; Wirla Maria da Silva Cunha Tamashiro; Patricia Ucelli Simioni
Journal:  Mediators Inflamm       Date:  2015-08-03       Impact factor: 4.711
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.