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Literature DB >> 11248410

Synthesis and in vitro antitumour activity evaluation of 1-aryl-1H,3H-thiazolo[4,3-b]quinazolines.

S Grasso¹, N Micale, A M Monforte, P Monforte, S Polimeni, M Zappalà.

Abstract

A series of 1H,3H-thiazolo[4,3-b]quinazolines (2a-i) were synthesized and evaluated for their in vitro antitumour activity against ca. 60 human tumour cell lines. They exhibited moderate (2c, 2d, 2f and 2g) to strong (2a, 2b, 2e, 2h and 2i) cell-growth inhibition at a concentration of 10(-4) M, but weak activity at lower concentrations. Only 1-(2,6-dichlorophenyl)-1H,3H-thiazolo[4,3-b]quinazoline (2h) possesses a significant growth inhibitory activity on 22 cell lines at a concentration of 10(-5) M.

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Year: 2000 PMID： 11248410 DOI： 10.1016/s0223-5234(00)01195-8

Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514

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Cited

4 in total

1. Organocatalysis in heterocyclic synthesis: DABCO as a mild and efficient catalytic system for the synthesis of a novel class of quinazoline, thiazolo [3,2-a]quinazoline and thiazolo[2,3-b] quinazoline derivatives.

Authors: Haider Behbehani; Hamada Mohamed Ibrahim
Journal: Chem Cent J Date: 2013-05-07 Impact factor: 4.215

Synthesis and in vitro antitumour activity evaluation of 1-aryl-1H,3H-thiazolo[4,3-b]quinazolines.

1. Organocatalysis in heterocyclic synthesis: DABCO as a mild and efficient catalytic system for the synthesis of a novel class of quinazoline, thiazolo [3,2-a]quinazoline and thiazolo[2,3-b] quinazoline derivatives.

2. Diversity oriented one-pot three-component sequential synthesis of annulated benzothiazoloquinazolines.

3. Syntheses of 3,4- and 1,4-dihydroquinazolines from 2-aminobenzylamine.

4. Synthesis of dihydroquinazolines from 2-aminobenzylamine: N ³ -aryl derivatives with electron-withdrawing groups.

Synthesis and in vitro antitumour activity evaluation of 1-aryl-1H,3H-thiazolo[4,3-b]quinazolines.

1. Organocatalysis in heterocyclic synthesis: DABCO as a mild and efficient catalytic system for the synthesis of a novel class of quinazoline, thiazolo [3,2-a]quinazoline and thiazolo[2,3-b] quinazoline derivatives.

2. Diversity oriented one-pot three-component sequential synthesis of annulated benzothiazoloquinazolines.

3. Syntheses of 3,4- and 1,4-dihydroquinazolines from 2-aminobenzylamine.

4. Synthesis of dihydroquinazolines from 2-aminobenzylamine: N 3 -aryl derivatives with electron-withdrawing groups.

4. Synthesis of dihydroquinazolines from 2-aminobenzylamine: N ³ -aryl derivatives with electron-withdrawing groups.