| Literature DB >> 11247666 |
G T Cicila1, M R Garrett, S J Lee, J Liu, H Dene, J P Rapp.
Abstract
It was previously shown using Dahl salt-sensitive (S) and salt-resistant (R) rats that a blood pressure quantitative trait locus (QTL) was present on rat chromosome 7. In the present work, this QTL was localized to a region less than 0.54 cM in size on the linkage map using a series of congenic strains. This region was contained in a single yeast artificial chromosome that was 220 kb long. This small segment still contained the primary candidate locus Cyp11b1 (11beta-hydroxylase), but the adjacent candidate genes Cyp11b2 (aldosterone synthase) and Cyp11b3 were ruled out. It is concluded that 11beta-hydroxylase, through its known genetic variants altering the production of 18-hydroxy-11-deoxy corticosterone, is very likely to account for the blood pressure QTL on chromosome 7 in the Dahl rat model of hypertension. This QTL accounts for about 23 mm Hg under the condition of 2% NaCl diet for 24 days. Copyright 2001 Academic Press.Entities:
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Year: 2001 PMID： 11247666 DOI： 10.1006/geno.2000.6442
Source DB: PubMed Journal: Genomics ISSN： 0888-7543 Impact factor: 5.736