Literature DB >> 1124737

The influence of carbenoxolone on steroid-induced ulcer and mucus secretion in the rat.

M Berg, A Geisel, H Necheles.   

Abstract

In rats, gastric mucus was decreased by starvation. The administration of carbenoxolone sodium, prednisolone, or their combination to starved rats brought the level of gastric mucus to that of nonstarved controls. Concomitant treatment with carbenoxolone sodium did not prevent prednisolone-induced ulceration of the glandular stomach in starved rats. The ulcerations of the prostomach (squamous spithelium)induced by starvation were prevented by carbenoxolone sodium, prednisolone, or the combination of the two.

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Year:  1975        PMID： 1124737     DOI： 10.1007/bf01072339

Source DB:  PubMed          Journal:  Am J Dig Dis        ISSN： 0002-9211


  20 in total

1.  HISTOPATHOLOGY OF STEROID-INDUCED ULCERS. AN EXPERIMENTAL STUDY IN THE RAT.

Authors:  A ROBERT; J E NEZAMIS
Journal:  Arch Pathol       Date:  1964-04

2.  TREATMENT OF GASTRIC ULCER WITH CARBENOXOLONE SODIUM AND OESTROGENS.

Authors:  R DOLL; I D HILL; C F HUTTON
Journal:  Gut       Date:  1965-02       Impact factor: 23.059

3.  EFFECT OF PREDNISOLONE ON GASTRIC MUCUS CONTENT AND ON ULCER FORMATION.

Authors:  A ROBERT; J E NEZAMIS
Journal:  Proc Soc Exp Biol Med       Date:  1963-12

4.  Triterpenoid liquorice compound in gastric and duodenal ulcer.

Authors:  R DOLL; I D HILL
Journal:  Lancet       Date:  1962-12-01       Impact factor: 79.321

5.  Starvation ulcer in the mouse.

Authors:  T OGAWA; T CHILES; H NECHELES
Journal:  Am J Physiol       Date:  1960-03

6.  Protection of gastric mucosa of the rat against ulceration by prefeeding with protein hydrolysates.

Authors:  H SHAY; M GRUENSTEIN
Journal:  Proc Soc Exp Biol Med       Date:  1948-11

Review 7.  Gastric mucus and the gastric mucous barrier. A review.

Authors:  R Menguy
Journal:  Am J Surg       Date:  1969-06       Impact factor: 2.565

8.  Protective action of deglycyrrhizinized liquorice on the occurrence of stomach ulcers in pylorus-ligated rats.

Authors:  S Andersson; F Bárány; J L Caboclo; T Mizuno
Journal:  Scand J Gastroenterol       Date:  1971       Impact factor: 2.423

9.  Quantitative and qualitative aspects of the plasma protein binding of carbenoxolone, an ulcer-healing drug.

Authors:  D V Parke; W E Lindup
Journal:  Ann N Y Acad Sci       Date:  1973-11-26       Impact factor: 5.691

10.  Morphological observations on gastric ulcers treated with carbenoxolone sodium.

Authors:  T E Goodier; L Horwich; R W Galloway
Journal:  Gut       Date:  1967-12       Impact factor: 23.059
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  3 in total

1.  Effect of cimetidine and carbenoxolone on cysteamine-induced ulcers: a study of gastric mucosal histamine and histamine formation capacity in rat.

Authors:  W K Man; S Boesby; R Mendez-Diaz; J Spencer
Journal:  Agents Actions       Date:  1984-12

Review 2.  Carbenoxolone: a review of its pharmacological properties and therapeutic efficacy in peptic ulcer disease.

Authors:  R M Pinder; R N Brogden; P R Sawyer; T M Speight; R Spencer; G S Avery
Journal:  Drugs       Date:  1976       Impact factor: 9.546

3.  Effects of carbenoxolone Na on acute and chronic gastric ulcer models in experimental animals.

Authors:  S Okabe; Y Takata; K Takeuchi; T Naganuma; K Takagi
Journal:  Am J Dig Dis       Date:  1976-08
  3 in total

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