[Spectrum of neuropsychological changes in multiple sclerosis].

Early disability of patients with multiple sclerosis at the able-bodied age is often caused by both a neurological disorder and the difficulties of their social and psychological adaptation that is aggravated significantly by higher cortical dysfunctions and by behavioral problems. The paper presents the results of the dynamic neuropsychological observation of 124 patients with multiple sclerosis and of their first degree relatives. Even at the early stage of the disease there were some cognitive disorders as worse transitent verbal, semantic, visual memory active attention and slower sensomotor reactions; difficulties in conceptual mentality. The cognitive functions, the activity of the disease, an actual psychological state, depression for example, and the expression of brain atrophy and the localization of the foci are bound by the certain way. The personality traits of patients and their close relatives testified a possible psychosomatic nature of this disease.