Literature DB >> 11245921

Splice isoforms of ubiquitous 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase in human brain.

R Kessler1, K Eschrich.   

Abstract

In human brain we were able to demonstrate sequence diversity of the ubiquitous 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/FBPase-2). Six different isoforms of PFK-2/FBPase-2, two of which are identical with the ubiquitous PFK-2/FBPase-2 and the inducible PFK-2, respectively, could be identified. The heterogeneity of human brain PFK-2/FBPase-2 isoforms is generated by alternative splicing. Three hitherto unrecognized exons were detected. The multiple PFK-2/FBPase-2 transcripts encode proteins which differ with respect to their length and to the amino acid composition of the carboxyl-termini. The isoform pattern of ubiquitous PFK-2/FBPase-2 is more complex in human brain than in skeletal muscle and liver.

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Year:  2001        PMID： 11245921     DOI： 10.1016/s0169-328x(01)00014-6

Source DB:  PubMed          Journal:  Brain Res Mol Brain Res        ISSN： 0169-328X


  17 in total

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Journal:  Biochem J       Date:  2004-08-01       Impact factor: 3.857

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3.  Analysis and interpretation of transcriptomic data obtained from extended Warburg effect genes in patients with clear cell renal cell carcinoma.

Authors:  Edward Sanders; Svenja Diehl
Journal:  Oncoscience       Date:  2015-02-17

4.  A role for inducible 6-phosphofructo-2-kinase in the control of neuronal glycolysis.

Authors:  Honggui Li; Xin Guo; Hang Xu; Shih-Lung Woo; Vera Halim; Caurnel Morgan; Chaodong Wu
Journal:  J Nutr Biochem       Date:  2012-12-14       Impact factor: 6.048

5.  6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB3) is up-regulated in high-grade astrocytomas.

Authors:  Renate Kessler; Franziska Bleichert; Jan-Peter Warnke; Klaus Eschrich
Journal:  J Neurooncol       Date:  2007-09-06       Impact factor: 4.130

6.  Nuclear targeting of 6-phosphofructo-2-kinase (PFKFB3) increases proliferation via cyclin-dependent kinases.

Authors:  Abdullah Yalcin; Brian F Clem; Alan Simmons; Andrew Lane; Kristin Nelson; Amy L Clem; Erin Brock; Deanna Siow; Binks Wattenberg; Sucheta Telang; Jason Chesney
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7.  The JAK2V617F oncogene requires expression of inducible phosphofructokinase/fructose-bisphosphatase 3 for cell growth and increased metabolic activity.

Authors:  M M Reddy; M S Fernandes; A Deshpande; E Weisberg; H V Inguilizian; O Abdel-Wahab; A L Kung; R L Levine; J D Griffin; M Sattler
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Review 8.  Cerebral Gluconeogenesis and Diseases.

Authors:  James Yip; Xiaokun Geng; Jiamei Shen; Yuchuan Ding
Journal:  Front Pharmacol       Date:  2017-01-04       Impact factor: 5.810

9.  6-Phosphofructo-2-kinase (PFKFB3) promotes cell cycle progression and suppresses apoptosis via Cdk1-mediated phosphorylation of p27.

Authors:  A Yalcin; B F Clem; Y Imbert-Fernandez; S C Ozcan; S Peker; J O'Neal; A C Klarer; A L Clem; S Telang; J Chesney
Journal:  Cell Death Dis       Date:  2014-07-17       Impact factor: 8.469

10.  Balancing glycolytic flux: the role of 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatases in cancer metabolism.

Authors:  Susana Ros; Almut Schulze
Journal:  Cancer Metab       Date:  2013-02-04
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