| Literature DB >> 11244030 |
Abstract
This review examines the role of cross-presentation in tolerance and immunity. We discuss (a) the antigenic requirements for cross-presentation, (b) the phenotype of the antigen presenting cell (APC), (c) the cellular interactions and molecular signals involved in cross-priming, and (d) the factors that direct the immune system toward tolerance or immunity. A large part of this review is dedicated to summarizing our current knowledge of the cross-presenting APC.Entities:
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Year: 2001 PMID: 11244030 DOI: 10.1146/annurev.immunol.19.1.47
Source DB: PubMed Journal: Annu Rev Immunol ISSN: 0732-0582 Impact factor: 28.527