Literature DB >> 11243860

Insulinomimetic bis(maltolato)zinc(II) complex: blood glucose normalizing effect in KK-A(y) mice with type 2 diabetes mellitus.

Y Yoshikawa1, E Ueda, H Miyake, H Sakurai, Y Kojima.   

Abstract

High blood glucose levels of KK-A(y) mice with type 2 diabetes mellitus were normalized by daily intraperitoneal (ip) administration of a zinc(II) complex, bis(maltolato)zinc(II) (Zn(Mal)(2)) with a Zn(O(4)) coordination mode, following the finding of strong in vitro insulinomimetic activity in isolated rat adipocytes treated with epinephrine in terms of the inhibition of free fatty acid release. The blood glucose level was maintained in the normal range during administration of the Zn(Mal)(2) complex for 14 days and improvements in the glucose tolerance were confirmed by an oral glucose tolerance test. Copyright 2001 Academic Press.

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Year:  2001        PMID： 11243860     DOI： 10.1006/bbrc.2001.4456

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  9 in total

1.  Zinc, zinc transporters and diabetes.

Authors:  J Rungby
Journal:  Diabetologia       Date:  2010-05-21       Impact factor: 10.122

2.  Molecular mechanism of antidiabetic zinc-allixin complexes: regulations of glucose utilization and lipid metabolism.

Authors:  Akihiro Nakayama; Makoto Hiromura; Yusuke Adachi; Hiromu Sakurai
Journal:  J Biol Inorg Chem       Date:  2008-02-21       Impact factor: 3.358

3.  A new insulin-mimetic bis(allixinato)zinc(II) complex: structure-activity relationship of zinc(II) complexes.

Authors:  Yusuke Adachi; Jiro Yoshida; Yukihiro Kodera; Akira Kato; Yutaka Yoshikawa; Yoshitane Kojima; Hiromu Sakurai
Journal:  J Biol Inorg Chem       Date:  2004-09-18       Impact factor: 3.358

4.  Bis(hinokitiolato)zinc complex ([Zn(hkt)2]) activates Akt/protein kinase B independent of insulin signal transduction.

Authors:  Yuki Naito; Yutaka Yoshikawa; Kazufumi Masuda; Hiroyuki Yasui
Journal:  J Biol Inorg Chem       Date:  2016-06-01       Impact factor: 3.358

5.  The effect of zinc supplementation on ghrelin-immunoreactive cells and lipid parameters in gastrointestinal tissue of streptozotocin-induced female diabetic rats.

Authors:  S Bolkent; R Yanardag; S Bolkent; O Mutlu; S Yildirim; K Kangawa; Y Minegishi; H Suzuki
Journal:  Mol Cell Biochem       Date:  2006-02-15       Impact factor: 3.396

6.  Effects of zinc supplementation on diabetes mellitus: a systematic review and meta-analysis.

Authors:  R Jayawardena; P Ranasinghe; P Galappatthy; Rldk Malkanthi; Gr Constantine; P Katulanda
Journal:  Diabetol Metab Syndr       Date:  2012-04-19       Impact factor: 3.320

Review 7.  Zinc and diabetes mellitus: understanding molecular mechanisms and clinical implications.

Authors:  Priyanga Ranasinghe; Shehani Pigera; Priyadarshani Galappatthy; Prasad Katulanda; Godwin R Constantine
Journal:  Daru       Date:  2015-09-17       Impact factor: 3.117

Review 8.  Type 2 Diabetes Mellitus (T2DM) and Carbohydrate Metabolism in Relation to T2DM from Endocrinology, Neurophysiology, Molecular Biology, and Biochemistry Perspectives.

Authors:  Hilla Mills; Ronald Acquah; Nova Tang; Luke Cheung; Susanne Klenk; Ronald Glassen; Magali Pirson; Alain Albert; Duong Trinh Hoang; Thang Nguyen Van
Journal:  Evid Based Complement Alternat Med       Date:  2022-08-09       Impact factor: 2.650

9.  Anti-Diabetic Effect of Organo-Chalcogen (Sulfur and Selenium) Zinc Complexes with Hydroxy-Pyrone Derivatives on Leptin-Deficient Type 2 Diabetes Model ob/ob Mice.

Authors:  Takayuki Nishiguchi; Yutaka Yoshikawa; Hiroyuki Yasui
Journal:  Int J Mol Sci       Date:  2017-12-07       Impact factor: 5.923
  9 in total

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