Literature DB >> 11242474

Peroxisome proliferator-activated receptor gamma, the ultimate liaison between fat and transcription.

S Rocchi1, J Auwerx.   

Abstract

The peroxisome proliferator-activated receptor gamma (PPARgamma) is nuclear receptor that controls the expression of a large number of genes involved in adipocyte differentiation, lipid storage and insulin sensitization. PPARgamma is bound and activated by fatty acid derivatives and prostaglandin J2. In addition, thiazolidinediones, non-steroidal anti-inflammatory drugs are synthetic ligands and agonists of this receptor. This review addresses the role of PPARgamma in obesity and diabetes.

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Year:  2000        PMID： 11242474     DOI： 10.1079/096582197388581

Source DB:  PubMed          Journal:  Br J Nutr        ISSN： 0007-1145            Impact factor:   3.718


  5 in total

Review 1.  Minireview: Challenges and opportunities in development of PPAR agonists.

Authors:  Matthew B Wright; Michele Bortolini; Moh Tadayyon; Martin Bopst
Journal:  Mol Endocrinol       Date:  2014-08-22

2.  Comparative molecular profiling of the PPARα/γ activator aleglitazar: PPAR selectivity, activity and interaction with cofactors.

Authors:  Michel Dietz; Peter Mohr; Bernd Kuhn; Hans Peter Maerki; Peter Hartman; Armin Ruf; Jörg Benz; Uwe Grether; Matthew B Wright
Journal:  ChemMedChem       Date:  2012-04-04       Impact factor: 3.466

3.  (-)-Hydroxycitric acid reduced fat deposition via regulating lipid metabolism-related gene expression in broiler chickens.

Authors:  Jing Han; Longlong Li; Dian Wang; Haitian Ma
Journal:  Lipids Health Dis       Date:  2016-02-24       Impact factor: 3.876

4.  Dietary Enteromorpha polysaccharide-Zn supplementation regulates amino acid and fatty acid metabolism by improving the antioxidant activity in chicken.

Authors:  Teketay Wassie; Xinyi Duan; Chunyan Xie; Ruxia Wang; Xin Wu
Journal:  J Anim Sci Biotechnol       Date:  2022-01-22

5.  Hypoglycemic Activity through a Novel Combination of Fruiting Body and Mycelia of Cordyceps militaris in High-Fat Diet-Induced Type 2 Diabetes Mellitus Mice.

Authors:  Sung-Hsun Yu; Szu-Yu Tina Chen; Wei-Shan Li; Navneet Kumar Dubey; Wei-Hong Chen; Jiunn-Jye Chuu; Sy-Jye Leu; Win-Ping Deng
Journal:  J Diabetes Res       Date:  2015-07-16       Impact factor: 4.011
  5 in total

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