| Literature DB >> 11241702 |
J B Mandeville1, B G Jenkins, B E Kosofsky, M A Moskowitz, B R Rosen, J J Marota.
Abstract
Functional MRI of rat brain was performed at 2 Tesla following intravenous injection of cocaine in order to 1) determine if changes in CBV and changes in BOLD signal were regionally coupled in brain parenchyma, and 2) compare the sensitivities of these imaging methods across different brain structures. Percent changes in CBV and BOLD relaxation rate were spatially and temporally coupled during this graded brain activation. The use of contrast agent increased functional sensitivity in all parenchymal brain structures, with a strong but predictable dependence on the resting-state blood volume fraction. Magn Reson Med 45:443-447, 2001. Copyright 2001 Wiley-Liss, Inc.Entities:
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Year: 2001 PMID： 11241702 DOI： 10.1002/1522-2594(200103)45:3<443::aid-mrm1058>3.0.co;2-3
Source DB: PubMed Journal: Magn Reson Med ISSN： 0740-3194 Impact factor: 4.668