Literature DB >> 11240021

Apolipoprotein E modulates glial activation and the endogenous central nervous system inflammatory response.

J R Lynch1, D Morgan, J Mance, W D Matthew, D T Laskowitz.   

Abstract

Apolipoprotein E (apoE) is a 299 amino acid protein that is associated with risk of developing Alzheimer's Disease (AD) and outcome after acute brain injury. To investigate the possibility that apoE modulates glial activation we studied the effect of endogenous apoE on inflammatory gene regulation in vitro and in vivo. Our results indicate that apoE downregulates CNS production of TNFalpha, Il-1beta, and Il-6 mRNA following stimulation with lipopolysaccharide (LPS). This effect of endogenous apoE on inflammatory gene regulation appears to be specific, and may account for the biological role that apoE plays in acute and chronic human neurological disease.

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Year:  2001        PMID： 11240021     DOI： 10.1016/s0165-5728(00)00459-8

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  58 in total

1.  Low-density lipoprotein receptors regulate microglial inflammation through c-Jun N-terminal kinase.

Authors:  Ana Pocivavsek; Mark P Burns; G William Rebeck
Journal:  Glia       Date:  2009-03       Impact factor: 7.452

2.  COG1410, a novel apolipoprotein-E mimetic, improves functional and morphological recovery in a rat model of focal brain ischemia.

Authors:  Elena A Tukhovskaya; Alexey Yu Yukin; Oksana N Khokhlova; Arkady N Murashev; Michael P Vitek
Journal:  J Neurosci Res       Date:  2009-02-15       Impact factor: 4.164

Review 3.  The role of apolipoprotein E in Guillain-Barré syndrome and experimental autoimmune neuritis.

Authors:  Hong-liang Zhang; Jiang Wu; Jie Zhu
Journal:  J Biomed Biotechnol       Date:  2010-02-16

4.  Apolipoprotein E epsilon 4 is associated with an increased vulnerability to cell death in Alzheimer's disease.

Authors:  C Frey; A Bonert; T Kratzsch; G Rexroth; W Rösch; F Müller-Spahn; K Maurer; W E Müller; A Eckert
Journal:  J Neural Transm (Vienna)       Date:  2006-06-01       Impact factor: 3.575

Review 5.  Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy.

Authors:  Chia-Chen Liu; Chia-Chan Liu; Takahisa Kanekiyo; Huaxi Xu; Guojun Bu
Journal:  Nat Rev Neurol       Date:  2013-01-08       Impact factor: 42.937

6.  The apoE-mimetic peptide, COG1410, improves functional recovery in a murine model of intracerebral hemorrhage.

Authors:  Daniel T Laskowitz; Beilei Lei; Hana N Dawson; Haichen Wang; Steven T Bellows; Dale J Christensen; Michael P Vitek; Michael L James
Journal:  Neurocrit Care       Date:  2012-04       Impact factor: 3.210

Review 7.  Peripheral versus central nervous system APOE in Alzheimer's disease: Interplay across the blood-brain barrier.

Authors:  Dustin Chernick; Stephanie Ortiz-Valle; Angela Jeong; Wenhui Qu; Ling Li
Journal:  Neurosci Lett       Date:  2019-06-07       Impact factor: 3.046

8.  APOE genotype-dependent modulation of astrocyte chemokine CCL3 production.

Authors:  Eiron Cudaback; Yue Yang; Thomas J Montine; C Dirk Keene
Journal:  Glia       Date:  2014-08-04       Impact factor: 7.452

9.  Polymorphisms of genes in the lipid metabolism pathway and risk of biliary tract cancers and stones: a population-based case-control study in Shanghai, China.

Authors:  Gabriella Andreotti; Jinbo Chen; Yu-Tang Gao; Asif Rashid; Bingshu E Chen; Philip Rosenberg; Lori C Sakoda; Jie Deng; Ming-Chang Shen; Bing-Sheng Wang; Tian-Quan Han; Bai-He Zhang; Meredith Yeager; Robert Welch; Stephen Chanock; Joseph F Fraumeni; Ann W Hsing
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2008-02-22       Impact factor: 4.254

10.  Inhibition of c-Jun N-terminal kinase increases apoE expression in vitro and in vivo.

Authors:  Ana Pocivavsek; G William Rebeck
Journal:  Biochem Biophys Res Commun       Date:  2009-07-15       Impact factor: 3.575
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