Literature DB >> 11239789

Is there a role for CEA in innate immunity in the colon?

S Hammarström1, V Baranov.   

Abstract

Carcinoembryonic antigen (CEA) is a well known tumor marker associated with the progression of colorectal tumors. The CEA family of glycoproteins has been fully characterized and the function of some of its members is now beginning to be understood. Here, we advance the hypothesis that, rather than functioning in cell adhesion as has been suggested previously, CEA plays a role in protecting the colonic mucosa from microbial invasion. This hypothesis is based on new microscopic, molecular, phylogenetic and microbiological evidence.

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Year:  2001        PMID： 11239789     DOI： 10.1016/s0966-842x(01)01952-7

Source DB:  PubMed          Journal:  Trends Microbiol        ISSN： 0966-842X            Impact factor:   17.079


  15 in total

Review 1.  Pathogenesis of Afa/Dr diffusely adhering Escherichia coli.

Authors:  Alain L Servin
Journal:  Clin Microbiol Rev       Date:  2005-04       Impact factor: 26.132

Review 2.  Pathogenesis of human diffusely adhering Escherichia coli expressing Afa/Dr adhesins (Afa/Dr DAEC): current insights and future challenges.

Authors:  Alain L Servin
Journal:  Clin Microbiol Rev       Date:  2014-10       Impact factor: 26.132

3.  CEACAM1 recognition by bacterial pathogens is species-specific.

Authors:  Maike Voges; Verena Bachmann; Robert Kammerer; Uri Gophna; Christof R Hauck
Journal:  BMC Microbiol       Date:  2010-04-20       Impact factor: 3.605

4.  Coevolution of activating and inhibitory receptors within mammalian carcinoembryonic antigen families.

Authors:  Robert Kammerer; Wolfgang Zimmermann
Journal:  BMC Biol       Date:  2010-02-04       Impact factor: 7.431

Review 5.  Pathogenic neisseriae: surface modulation, pathogenesis and infection control.

Authors:  Mumtaz Virji
Journal:  Nat Rev Microbiol       Date:  2009-04       Impact factor: 60.633

6.  Carcinoembryonic antigen (CEA) and CEA-related cell adhesion molecule 1 (CEACAM1), apically expressed on human colonic M cells, are potential receptors for microbial adhesion.

Authors:  Vladimir Baranov; Sten Hammarström
Journal:  Histochem Cell Biol       Date:  2004-01-31       Impact factor: 4.304

7.  Increased expression of antimicrobial peptides and lysozyme in colonic epithelial cells of patients with ulcerative colitis.

Authors:  A Fahlgren; S Hammarström; A Danielsson; M-L Hammarström
Journal:  Clin Exp Immunol       Date:  2003-01       Impact factor: 4.330

8.  Role of serum carcinoembryonic antigen in the detection of colorectal cancer before and after surgical resection.

Authors:  Bin-Bin Su; Hui Shi; Jun Wan
Journal:  World J Gastroenterol       Date:  2012-05-07       Impact factor: 5.742

9.  Mutual Regulation of TLR/NLR and CEACAM1 in the Intestinal Microvasculature: Implications for IBD Pathogenesis and Therapy.

Authors:  Anja Schirbel; Nancy Rebert; Tammy Sadler; Gail West; Florian Rieder; Christoph Wagener; Andrea Horst; Andreas Sturm; Carol de la Motte; Claudio Fiocchi
Journal:  Inflamm Bowel Dis       Date:  2019-01-10       Impact factor: 5.325

10.  IFN-gamma amplifies NFkappaB-dependent Neisseria meningitidis invasion of epithelial cells via specific upregulation of CEA-related cell adhesion molecule 1.

Authors:  Natalie J Griffiths; Christopher J Bradley; Robert S Heyderman; Mumtaz Virji
Journal:  Cell Microbiol       Date:  2007-08-30       Impact factor: 3.715
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