| Literature DB >> 11239162 |
J Yoder1, C Pham, Y M Iizuka, O Kanagawa, S K Liu, J McGlade, A M Cheng.
Abstract
GADS is an adaptor protein implicated in CD3 signaling because of its ability to link SLP-76 to LAT. A GADS-deficient mouse was generated by gene targeting, and the function of GADS in T cell development and activation was examined. GADS- CD4-CD8- thymocytes exhibited a severe block in proliferation but still differentiated into mature T cells. GADS- thymocytes failed to respond to CD3 cross-linking in vivo and were impaired in positive and negative selection. Immunoprecipitation experiments revealed that the association between SLP-76 and LAT was uncoupled in GADS- thymocytes. These observations indicate that GADS is a critical adaptor for CD3 signaling.Entities:
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Year: 2001 PMID： 11239162 DOI： 10.1126/science.1057176
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728