Literature DB >> 11237260

Inhibition of human topoisomerase II by the antitumor metallocenes.

G Mokdsi1, M M Harding.   

Abstract

The ability of antitumor active metallocenes Cp2MCl2, (M=Ti, V, Mo, Nb) and the biologically inactive derivative (MeCp)2TiCl2, to inhibit the relaxation of supercoiled plasmid DNA pBR322 by human topoisomerase II has been studied by gel electrophoresis. All metallocenes inhibit the enzyme with maximum inhibition observed at 2.0 mM (Cp2TiCl2), 3.0 mM (Cp2MoCl2), 0.2 mM (Cp2NbCl2), 0.25 mM (Cp2VCl2) and 2.0 mM (MeCpTiCl2). The implications for the mechanism of antitumor activity of the metallocene dihalides are discussed.

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Year:  2001        PMID： 11237260     DOI： 10.1016/s0162-0134(00)00198-7

Source DB:  PubMed          Journal:  J Inorg Biochem        ISSN： 0162-0134            Impact factor:   4.155


  9 in total

1.  Toxic and Physiological Metal Uptake and Release by Human Serum Transferrin.

Authors:  David J Reilley; Jack T Fuller; Michael R Nechay; Marie Victor; Wei Li; Josiah D Ruberry; Jon I Mujika; Xabier Lopez; Anastassia N Alexandrova
Journal:  Biophys J       Date:  2020-05-20       Impact factor: 4.033

2.  Intracellular mapping of the distribution of metals derived from the antitumor metallocenes.

Authors:  Jenny B Waern; Hugh H Harris; Barry Lai; Zhonghou Cai; Margaret M Harding; Carolyn T Dillon
Journal:  J Biol Inorg Chem       Date:  2005-09-23       Impact factor: 3.358

3.  Anticancer activity and mode of action of titanocene C.

Authors:  Ulrike Olszewski; James Claffey; Megan Hogan; Matthias Tacke; Robert Zeillinger; Patrick J Bednarski; Gerhard Hamilton
Journal:  Invest New Drugs       Date:  2010-02-17       Impact factor: 3.850

4.  Interaction of metallocene dichlorides with apo-human transferrin: A spectroscopic study and cytotoxic activity against human cancer cell lines.

Authors:  Jorge R Güette Fernández; Xiomara Narváez Pita; Enrique Meléndez; Elsie I Parés Matos
Journal:  Int J Mol Biol (Edmond)       Date:  2020-07-31

5.  In Search for Titanocene Complexes with Improved Cytotoxic Activity: Synthesis, X-Ray Structure, and Spectroscopic Study of Bis(eta-cyclopentadienyl)difluorotitanium(IV).

Authors:  Elias Koleros; Theocharis C Stamatatos; Vassilis Psycharis; Catherine P Raptopoulou; Spyros P Perlepes; Nikolaos Klouras
Journal:  Bioinorg Chem Appl       Date:  2010-06-23       Impact factor: 7.778

6.  A proposed mechanism for the inhibitory effect of the anticancer agent titanocene dichloride on tumour gelatinases and other proteolytic enzymes.

Authors:  Maria Pavlaki; Katerina Debeli; Irene-Eva Triantaphyllidou; Nikolaos Klouras; Eleftheria Giannopoulou; Alexios J Aletras
Journal:  J Biol Inorg Chem       Date:  2009-04-24       Impact factor: 3.358

7.  Are cucurbiturils better drug carriers for bent metallocenes? Insights from theory.

Authors:  Dhurairajan Senthilnathan; Rajadurai Vijay Solomon; Shanmugam Kiruthika; Ponnambalam Venuvanalingam; Mahesh Sundararajan
Journal:  J Biol Inorg Chem       Date:  2018-03-03       Impact factor: 3.358

Review 8.  Organometallic anticancer compounds.

Authors:  Gilles Gasser; Ingo Ott; Nils Metzler-Nolte
Journal:  J Med Chem       Date:  2010-11-15       Impact factor: 7.446

9.  Evaluating Ligand Modifications of the Titanocene and Auranofin Moieties for the Development of More Potent Anticancer Drugs.

Authors:  Lauren Fernandez-Vega; Valeria A Ruiz Silva; Tania M Domínguez-González; Sebastián Claudio-Betancourt; Rafael E Toro-Maldonado; Luisa C Capre Maso; Karina Sanabria Ortiz; Jean A Pérez-Verdejo; Janeishly Román González; Grecia T Rosado-Fraticelli; Fabiola Pagán Meléndez; Fabiola M Betancourt Santiago; Daniel A Rivera-Rivera; Carlos Martínez Navarro; Andrea C Bruno Chardón; Axel O Vera; Arthur D Tinoco
Journal:  Inorganics (Basel)       Date:  2020-01-26
  9 in total

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