Literature DB >> 11237062

The role of AP-1 in glucocorticoid resistance in leukaemia.

S Bailey1, A G Hall, A D Pearson, C P Redfern.   

Abstract

Glucocorticoids are used in the treatment of acute lymphoblastic leukaemia (ALL) and chronic lymphocytic leukaemia (CLL) but many patients develop glucocorticoid resistance on relapse. The ligand-activated glucocorticoid receptor inhibits activity of the AP-1 transcription factor and the purpose of this study was to test the hypothesis that up-regulation or overexpression of AP1-binding activity may be an important mechanism of glucocorticoid resistance in ALL and CLL. In vitro sensitivity of patient blasts to prednisolone was measured using th

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Year:  2001        PMID： 11237062     DOI： 10.1038/sj.leu.2402039

Source DB:  PubMed          Journal:  Leukemia        ISSN： 0887-6924            Impact factor:   11.528


  6 in total

Review 1.  Molecular pharmacodynamics in childhood leukemia.

Authors:  R Pieters; M L den Boer
Journal:  Int J Hematol       Date:  2003-12       Impact factor: 2.490

2.  EBV infection induces expression of the transcription factors ATF-2/c-Jun in B lymphocytes but not in B-CLL cells.

Authors:  Kentaro Bandobashi; Anquan Liu; Noémi Nagy; Loránd L Kis; Jun Nishikawa; Magnus Björkholm; George Klein; Eva Klein
Journal:  Virus Genes       Date:  2005-05       Impact factor: 2.332

3.  Differential heat shock protein localization in chronic lymphocytic leukemia.

Authors:  Nina C Dempsey; Francesca Leoni; H Elyse Ireland; Christine Hoyle; John H H Williams
Journal:  J Leukoc Biol       Date:  2009-12-10       Impact factor: 4.962

4.  Identification of early growth response protein 1 (EGR-1) as a novel target for JUN-induced apoptosis in multiple myeloma.

Authors:  Lijuan Chen; Siqing Wang; Yiming Zhou; Xiaosong Wu; Igor Entin; Joshua Epstein; Shmuel Yaccoby; Wei Xiong; Bart Barlogie; John D Shaughnessy; Fenghuang Zhan
Journal:  Blood       Date:  2009-10-16       Impact factor: 22.113

5.  The Roles of Mitogen-Activated Protein Kinase Pathways in TGF-β-Induced Epithelial-Mesenchymal Transition.

Authors:  Ting Gui; Yujing Sun; Aiko Shimokado; Yasuteru Muragaki
Journal:  J Signal Transduct       Date:  2012-01-29

6.  The long noncoding RNA HOTAIRM1 controlled by AML1 enhances glucocorticoid resistance by activating RHOA/ROCK1 pathway through suppressing ARHGAP18.

Authors:  Liang Liang; Wenbin Gu; Meng Li; Ran Gao; Xin Zhang; Chongye Guo; Shuangli Mi
Journal:  Cell Death Dis       Date:  2021-07-14       Impact factor: 8.469
  6 in total

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