BACKGROUND: The systemic inflammatory reaction (SIR) is assumed to be one of the factors that causes cerebral dysfunction after cardiopulmonary bypass (CPB). The aim of the present study was to evaluate the relationship between the SIR and postoperative cognitive performance at 5 days and 3 months. METHODS: One hundred patients undergoing coronary artery bypass grafting were studied. Inflammatory markers and markers of coagulation and fibrinolysis were determined at several time points during and after the operation. Correlation analysis between maximum levels of the different markers and early and late performance was performed. RESULTS: No overall association was found between the maximum levels of the inflammatory markers and early and late function. CONCLUSIONS: Notwithstanding limitations of statistical power established markers of systemic inflammatory reaction showed no relationship with outcome at 5-day or 3-month follow-up in this subset of patients.
BACKGROUND: The systemic inflammatory reaction (SIR) is assumed to be one of the factors that causes cerebral dysfunction after cardiopulmonary bypass (CPB). The aim of the present study was to evaluate the relationship between the SIR and postoperative cognitive performance at 5 days and 3 months. METHODS: One hundred patients undergoing coronary artery bypass grafting were studied. Inflammatory markers and markers of coagulation and fibrinolysis were determined at several time points during and after the operation. Correlation analysis between maximum levels of the different markers and early and late performance was performed. RESULTS: No overall association was found between the maximum levels of the inflammatory markers and early and late function. CONCLUSIONS: Notwithstanding limitations of statistical power established markers of systemic inflammatory reaction showed no relationship with outcome at 5-day or 3-month follow-up in this subset of patients.
Authors: Alex Bekker; Michael Haile; Richard Kline; Sorosch Didehvar; Ramesh Babu; Frank Martiniuk; Michael Urban Journal: J Neurosurg Anesthesiol Date: 2013-01 Impact factor: 3.956
Authors: Fredrik S Yannopoulos; Oiva Arvola; Henri Haapanen; Johanna Herajärvi; Ilkka Miinalainen; Hanna Jensen; Kai Kiviluoma; Tatu Juvonen Journal: Interact Cardiovasc Thorac Surg Date: 2013-12-16
Authors: Endre Nemeth; Katalin Vig; Kristof Racz; Kinga B Koritsanszky; Klara I Ronkay; Fumiko P Hamvas; Csaba Borbély; Ajandek Eory; Bela Merkely; Janos Gal Journal: BMC Anesthesiol Date: 2017-08-29 Impact factor: 2.217