| Literature DB >> 11233998 |
M Gentilli1, J X Mazoit, H Bouaziz, D Fletcher, R F Casper, D Benhamou, J F Savouret.
Abstract
The effect of resveratrol, an aryl hydrocarbon receptor (AhR) antagonist, known to inhibit inducible cyclooxygenase-2 (COX2) and its transcription were examined in a model of hyperalgesia induced by carrageenan in the rat. Pretreatment with resveratrol did not reverse swelling and edema, but reversed the hyperalgesia induced by local tissue injury provoked by carrageenan. This reversal, occurring at resveratrol concentrations as low as 2 mg/kg, lasted for at least 48 hours. The link with COX2 activity inhibition and COX2 gene transcription, as well as a potential AhR inhibitory effect, remain to be established.Entities:
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Year: 2001 PMID： 11233998 DOI： 10.1016/s0024-3205(00)01018-3
Source DB: PubMed Journal: Life Sci ISSN： 0024-3205 Impact factor: 5.037