Antiviral activity of the products of cyclization of dimethyl 2-[(1-arylamino-1-arylmethylidene)hydrazono]succinate.

In this research, conditions of cyclization of dimethyl 2-[(1-arylamino-1-arylmethylidene)hydrazono]succinate 1-5 leading to the formation of 3,4-diaryl-5-carboxymethyl-1,2,4-triazole 6-10 and methyl 2-(5-oxo-3,4-diaryl-1,4,5,6-tetrahydro-1,2,4-triazine-6-ylidene)acetates 11-15 and the biological activity of some of them have been examined. Their chemical structures were confirmed by IR, 1H-NMR, EI-MS and elemental analysis. Substances 8 and 13 exhibited moderate virucidal activity and partially inhibited absorption of the viruses to the susceptible cells. The acute toxicity of compounds 6-10 was established. For compounds 8 and 13, the influence on the central nervous system of mice and rats in behavioral tests was examined.