Literature DB >> 11229757

Identification and characterization of a potential ischemia-selective N-methyl-D-aspartate (NMDA) receptor ion-channel blocker, CNS 5788.

S Padmanabhan1, M E Perlman, L Zhang, D Moore, D Zhou, J B Fischer, G J Durant, R N McBurney.   

Abstract

The identification and characterization of a potentially ischemia-selective and orally-active sulfoxide based NMDA ion-channel blocker showing good neuroprotective activity, (R)-(+)-N-(2-chloro-5-methylthiophenyl)-N'-(3-methylsulfinylphenyl)-N'-methylguanidine (CNS 5788), is described.

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Year:  2001        PMID： 11229757     DOI： 10.1016/s0960-894x(00)00695-8

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  New N-aryl-N'-(3-(substituted)phenyl)-N'-methylguanidines as leads to potential PET radioligands for imaging the open NMDA receptor.

Authors:  Gregory R Naumiec; Lisheng Cai; Victor W Pike
Journal:  Bioorg Med Chem Lett       Date:  2014-11-29       Impact factor: 2.823

2.  N'-3-(Trifluoromethyl)phenyl Derivatives of N-Aryl-N'-methylguanidines as Prospective PET Radioligands for the Open Channel of the N-Methyl-d-aspartate (NMDA) Receptor: Synthesis and Structure-Affinity Relationships.

Authors:  Gregory R Naumiec; Kimberley J Jenko; Sami S Zoghbi; Robert B Innis; Lisheng Cai; Victor W Pike
Journal:  J Med Chem       Date:  2015-12-04       Impact factor: 7.446

3.  Exploring the Use of a Guanine-Rich Catalytic DNA for Sulfoxide Preparation.

Authors:  María A Dellafiore; Javier M Montserrat; Adolfo M Iribarren
Journal:  PLoS One       Date:  2015-06-12       Impact factor: 3.240
  3 in total

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