Literature DB >> 11229751

Synthesis and antitumor evaluation of novel monoindolyl-4-trifluoromethylpyridines and bisindolyl-4-trifluoromethylpyridines.

B Jiang1, X N Xiong, C G Yang.   

Abstract

A series of novel monoindolyl-4-trifluoromethylpyridines and bisindolyl-4-trifluoromethylpyridines was designed and synthesized as potential antitumor agents. They were evaluated for preliminary cytotoxic activity against P388 and A-549 cells with IC50 values. 4-Trifluoromethyl-2,6-bis[3'-(N-tosyl-6'-methoxyl-indolyl)] pyridine was identified as the most potent in this series.

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Year:  2001        PMID： 11229751     DOI： 10.1016/s0960-894x(00)00704-6

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

1.  Synthesis and antiproliferative activity of thiazolyl-bis-pyrrolo[2,3-b]pyridines and indolyl-thiazolyl-pyrrolo[2,3-c]pyridines, nortopsentin analogues.

Authors:  Anna Carbone; Barbara Parrino; Gloria Di Vita; Alessandro Attanzio; Virginia Spanò; Alessandra Montalbano; Paola Barraja; Luisa Tesoriere; Maria Antonia Livrea; Patrizia Diana; Girolamo Cirrincione
Journal:  Mar Drugs       Date:  2015-01-16       Impact factor: 5.118

2.  3-[4-(1H-indol-3-yl)-1,3-thiazol-2-yl]-1H-pyrrolo[2,3-b]pyridines, nortopsentin analogues with antiproliferative activity.

Authors:  Barbara Parrino; Anna Carbone; Gloria Di Vita; Cristina Ciancimino; Alessandro Attanzio; Virginia Spanò; Alessandra Montalbano; Paola Barraja; Luisa Tesoriere; Maria Antonia Livrea; Patrizia Diana; Girolamo Cirrincione
Journal:  Mar Drugs       Date:  2015-04-03       Impact factor: 5.118

3.  Retracted Article: The synthesis and biological activity of marine alkaloid derivatives and analogues.

Authors:  Shiyang Zhou; Gangliang Huang
Journal:  RSC Adv       Date:  2020-08-28       Impact factor: 4.036

4.  Synthesis and antiproliferative activity of 2,5-bis(3'-indolyl)pyrroles, analogues of the marine alkaloid nortopsentin.

Authors:  Anna Carbone; Barbara Parrino; Paola Barraja; Virginia Spanò; Girolamo Cirrincione; Patrizia Diana; Armin Maier; Gerhard Kelter; Heinz-Herbert Fiebig
Journal:  Mar Drugs       Date:  2013-03-01       Impact factor: 5.118
  4 in total

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