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Literature DB >> 11228416

T cell fate specification and alphabeta/gammadelta lineage commitment.

Abstract

The development of T cells from pluripotent stem cells involves a coordinated series of lineage-commitment steps. Common lymphoid precursors in the fetal liver or adult bone marrow must first choose between a T, B or NK cell fate. Committed T cell precursors in the thymus then differentiate into cells committed to the alphabeta or gammadelta lineages. Recent advances have been made in our understanding of the mechanisms underlying T cell fate specification and alphabeta/gammadelta lineage divergence.

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Year: 2001 PMID： 11228416 DOI： 10.1016/s0952-7915(00)00207-7

Source DB: PubMed Journal: Curr Opin Immunol ISSN： 0952-7915 Impact factor: 7.486

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Cited

7 in total

1. T cells develop normally in the absence of both Deltex1 and Deltex2.

Authors: Sophie M Lehar; Michael J Bevan
Journal: Mol Cell Biol Date: 2006-08-21 Impact factor: 4.272

2. Human alpha beta and gamma delta thymocyte development: TCR gene rearrangements, intracellular TCR beta expression, and gamma delta developmental potential--differences between men and mice.

Authors: Michelle L Joachims; Jennifer L Chain; Scott W Hooker; Christopher J Knott-Craig; Linda F Thompson
Journal: J Immunol Date: 2006-02-01 Impact factor: 5.422

3. T cells developing in fetal thymus of T-cell receptor alpha-chain transgenic mice colonize gammadelta T-cell-specific epithelial niches but lack long-term reconstituting potential.

Authors: Karin Leandersson; Elin Jaensson; Fredrik Ivars
Journal: Immunology Date: 2006-09 Impact factor: 7.397

4. Evolution and Potential Subfunctionalization of Duplicated fms-Related Class III Receptor Tyrosine Kinase flt3s and Their Ligands in the Allotetraploid Xenopus laevis.

Authors: Matthieu Paiola; Siyuan Ma; Jacques Robert
Journal: J Immunol Date: 2022-08-05 Impact factor: 5.426

T cell fate specification and alphabeta/gammadelta lineage commitment.

1. T cells develop normally in the absence of both Deltex1 and Deltex2.

2. Human alpha beta and gamma delta thymocyte development: TCR gene rearrangements, intracellular TCR beta expression, and gamma delta developmental potential--differences between men and mice.

3. T cells developing in fetal thymus of T-cell receptor alpha-chain transgenic mice colonize gammadelta T-cell-specific epithelial niches but lack long-term reconstituting potential.

4. Evolution and Potential Subfunctionalization of Duplicated fms-Related Class III Receptor Tyrosine Kinase flt3s and Their Ligands in the Allotetraploid Xenopus laevis.

5. T-cell differentiation of multipotent hematopoietic cell line EML in the OP9-DL1 coculture system.

6. Notch ligands Delta 1 and Jagged1 transmit distinct signals to T-cell precursors.

7. T cell receptor specificity is critical for the development of epidermal gammadelta T cells.