Literature DB >> 11228360

Protective responses against experimental Mycobacterium leprae infection in mice induced by recombinant Bacillus Calmette-Guérin over-producing three putative protective antigen candidates.

N Ohara1, M Matsuoka, H Nomaguchi, M Naito, T Yamada.   

Abstract

The components of Ag85 (Ag85A, Ag85B, and Ag85C) are putative protective antigen candidates against mycobacterial infection. A recombinant Mycobacterium bovis Bacillus Calmette-Guérin (rBCG) over-producing Ag85A, Ag85B, and MPB51 (rBCG/BA51) was constructed. rBCG/BA51 could secrete these antigens at levels more than five times higher than parental BCG. Immunization of C57BL/6 and BALB/c mice with this rBCG reduced the multiplication of Mycobacterium leprae in the foot pads of both strains of mice. The inhibition by rBCG/BA51 was more evident than that by parental BCG.

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Year:  2001        PMID： 11228360     DOI： 10.1016/s0264-410x(00)00439-4

Source DB:  PubMed          Journal:  Vaccine        ISSN： 0264-410X            Impact factor:   3.641


  7 in total

Review 1.  Advances and hurdles on the way toward a leprosy vaccine.

Authors:  Malcolm S Duthie; Thomas P Gillis; Steven G Reed
Journal:  Hum Vaccin       Date:  2011-11-01

2.  Construction and characterization of bivalent vaccine candidate expressing HspA and M(r)18,000 OMP from Helicobacter pylori.

Authors:  Zheng Jiang; Ai-Long Huang; Xiao-Hong Tao; Pi-Long Wang
Journal:  World J Gastroenterol       Date:  2003-08       Impact factor: 5.742

3.  Antigen-specific cellular and humoral responses are induced by intradermal Mycobacterium leprae infection of the mouse ear.

Authors:  Malcolm S Duthie; Stephen T Reece; Ramanuj Lahiri; Wakako Goto; Vanitha S Raman; Juliette Kaplan; Greg C Ireton; Sylvie Bertholet; Thomas P Gillis; James L Krahenbuhl; Steven G Reed
Journal:  Infect Immun       Date:  2007-08-27       Impact factor: 3.441

4.  rBCG30-induced immunity and cross-protection against Mycobacterium leprae challenge are enhanced by boosting with the Mycobacterium tuberculosis 30-kilodalton antigen 85B.

Authors:  Thomas P Gillis; Michael V Tullius; Marcus A Horwitz
Journal:  Infect Immun       Date:  2014-07-07       Impact factor: 3.441

5.  Inhibition of the multiplication of Mycobacterium leprae by vaccination with a recombinant M. bovis BCG strain that secretes major membrane protein II in mice.

Authors:  Y Maeda; T Tamura; M Matsuoka; M Makino
Journal:  Clin Vaccine Immunol       Date:  2009-08-12

6.  Immunogenicity of recombinant BCG vaccine strains overexpressing components of the antigen 85 complex of Mycobacterium tuberculosis.

Authors:  Neeraj Dhar; Vivek Rao; Anil K Tyagi
Journal:  Med Microbiol Immunol       Date:  2003-08-02       Impact factor: 3.402

Review 7.  Combination chemoprophylaxis and immunoprophylaxis in reducing the incidence of leprosy.

Authors:  Malcolm S Duthie; Marivic F Balagon
Journal:  Risk Manag Healthc Policy       Date:  2016-04-27
  7 in total

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