Literature DB >> 11227733

RET proto-oncogene mutation in a mixed medullary-follicular thyroid carcinoma.

F Orlandi1, E Chiefari, P Caraci, A Mussa, I Gonzatto, P De Giuli, D Giuffrida, A Angeli, S Filetti.   

Abstract

A case of a patient with an uncommon thyroid carcinoma, showing histological and immunohistochemical features of both follicular and parafollicular cells is described. Somatic point mutation (ATG to ACG heterozygotic mutation at codon 918) of the RET proto-oncogene was detected in tumor tissue, as confirmed by immunohistochemical expression of RET oncoprotein. Our findings suggest that constitutive RET proto-oncogene activation may be involved in the development of mixed medullary-follicular thyroid carcinoma.

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Year:  2001        PMID： 11227733     DOI： 10.1007/BF03343809

Source DB:  PubMed          Journal:  J Endocrinol Invest        ISSN： 0391-4097            Impact factor:   4.256


  19 in total

Review 1.  Current diagnosis and management of medullary thyroid carcinoma.

Authors:  D Giuffrida; H Gharib
Journal:  Ann Oncol       Date:  1998-07       Impact factor: 32.976

Review 2.  Mixed medullary and follicular carcinoma of the thyroid.

Authors:  M Sobrinho-Simŏes
Journal:  Histopathology       Date:  1993-09       Impact factor: 5.087

3.  The ultimobranchial gland and congenital thyroid abnormalities in man.

Authors:  E D Williams; C E Toyn; H R Harach
Journal:  J Pathol       Date:  1989-10       Impact factor: 7.996

4.  Carcinoma of the thyroid with a mixed medullary and follicular pattern: morphologic, immunohistochemical, and clinical laboratory studies.

Authors:  M Hales; W Rosenau; M D Okerlund; M Galante
Journal:  Cancer       Date:  1982-10-01       Impact factor: 6.860

5.  Experimental carcinogenesis in the thyroid follicular and C cells. A comparison of the effect of variation in dietary calcium and of radiation.

Authors:  S M Triggs; E D Williams
Journal:  Acta Endocrinol (Copenh)       Date:  1977-05

6.  Analysis of RET proto-oncogene abnormalities in patients with MEN 2A, MEN 2B, familial or sporadic medullary thyroid carcinoma.

Authors:  E Chiefari; D Russo; D Giuffrida; G A Zampa; D Meringolo; F Arturi; I Chiodini; D Bianchi; M Attard; V Trischitta; R Bruno; P Giannasio; A Pontecorvi; S Filetti
Journal:  J Endocrinol Invest       Date:  1998-06       Impact factor: 4.256

7.  Concurrent medullary and papillary carcinomas of thyroid with lymph node metastases. A collision phenomenon.

Authors:  G C Pastolero; C I Coire; S L Asa
Journal:  Am J Surg Pathol       Date:  1996-02       Impact factor: 6.394

8.  Medullary carcinoma of the thyroid gland. Clinical, pathological, and immunohistochemical features with review of the literature.

Authors:  M Uribe; C M Fenoglio-Preiser; M Grimes; C Feind
Journal:  Am J Surg Pathol       Date:  1985-08       Impact factor: 6.394

9.  Study of calcitonin and thyroglobulin gene expression in human mixed follicular and medullary thyroid carcinoma.

Authors:  M Noel; M C Delehaye; N Segond; F Lasmoles; B Caillou; P Gardet; P Fragu; M S Moukhtar
Journal:  Thyroid       Date:  1991       Impact factor: 6.568

10.  Somatic mutations of the ret protooncogene in sporadic medullary thyroid carcinoma are not restricted to exon 16 and are associated with tumor recurrence.

Authors:  C Romei; R Elisei; A Pinchera; I Ceccherini; E Molinaro; F Mancusi; E Martino; G Romeo; F Pacini
Journal:  J Clin Endocrinol Metab       Date:  1996-04       Impact factor: 5.958
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  2 in total

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Review 2.  Goblet cell carcinoids and other mixed neuroendocrine/nonneuroendocrine neoplasms.

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  2 in total

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