Current problems of amebiasis in Japan and recent advances in amebiasis research.

Amebiasis is epidemic in two major populations in Japan: male homosexuals and institutionalized people. Currently available diagnostic, chemotherapeutic, and prophylactic measures and their problems are discussed. Recent advances in basic research on amebiasis are also described with new findings of unique metabolisms and intracellular structures and organization. Discoveries and analyses of the unique features presented by this parasitic protist help in our elucidation of the pathogenic mechanisms of the parasite and may eventually lead to the development of new drugs and vaccines against amebiasis.