Literature DB >> 11224523

Inactivation of Notch 1 in immature thymocytes does not perturb CD4 or CD8T cell development.

A Wolfer1, T Bakker, A Wilson, M Nicolas, V Ioannidis, D R Littman, P P Lee, C B Wilson, W Held, H R MacDonald, F Radtke.   

Abstract

Notch proteins influence cell-fate decisions in many developing systems. Several gain-of-function studies have suggested a critical role for Notch 1 signaling in CD4-CD8 lineage commitment, maturation and survival in the thymus. However, we show here that tissue-specific inactivation of the gene encoding Notch 1 in immature (CD25+CD44-)T cell precursors does not affect subsequent thymocyte development. Neither steady-state numbers nor the rate of production of CD4+ and CD8+ mature thymocytes is perturbed in the absence of Notch 1. In addition, Notch 1-deficient thymocytes are normally sensitive to spontaneous or glucocorticoid-induced apoptosis. In contrast to earlier reports, these data formally exclude an essential role for Notch 1 in CD4-CD8 lineage commitment, maturation or survival.

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Year:  2001        PMID： 11224523     DOI： 10.1038/85294

Source DB:  PubMed          Journal:  Nat Immunol        ISSN： 1529-2908            Impact factor:   25.606


  115 in total

1.  Presenilin-dependent gamma-secretase activity modulates thymocyte development.

Authors:  P Doerfler; M S Shearman; R M Perlmutter
Journal:  Proc Natl Acad Sci U S A       Date:  2001-07-24       Impact factor: 11.205

2.  Notch1 confers a resistance to glucocorticoid-induced apoptosis on developing thymocytes by down-regulating SRG3 expression.

Authors:  Y I Choi; S H Jeon; J Jang; S Han; J K Kim; H Chung; H W Lee; H Y Chung; S D Park; R H Seong
Journal:  Proc Natl Acad Sci U S A       Date:  2001-08-14       Impact factor: 11.205

3.  Induction of thymocyte positive selection does not convey immediate resistance to negative selection.

Authors:  Katherine J Hare; Judit Pongracz; Eric J Jenkinson; Graham Anderson
Journal:  Immunology       Date:  2002-02       Impact factor: 7.397

4.  E-cadherin promotes accumulation of a unique memory CD8 T-cell population in murine salivary glands.

Authors:  Maike Hofmann; Hanspeter Pircher
Journal:  Proc Natl Acad Sci U S A       Date:  2011-09-19       Impact factor: 11.205

5.  Notch ligation by Delta1 inhibits peripheral immune responses to transplantation antigens by a CD8+ cell-dependent mechanism.

Authors:  Kenneth K Wong; Matthew J Carpenter; Lesley L Young; Susan J Walker; Grahame McKenzie; Alyson J Rust; George Ward; Laura Packwood; Karen Wahl; Luc Delriviere; Gerard Hoyne; Paul Gibbs; Brian R Champion; Jonathan R Lamb; Margaret J Dallman
Journal:  J Clin Invest       Date:  2003-12       Impact factor: 14.808

Review 6.  The notch pathway: modulation of cell fate decisions in hematopoiesis.

Authors:  K Ohishi; B Varnum-Finney; I D Bernstein
Journal:  Int J Hematol       Date:  2002-06       Impact factor: 2.490

Review 7.  Transcriptional control of thymocyte positive selection.

Authors:  Gilbert J Kersh
Journal:  Immunol Res       Date:  2004       Impact factor: 2.829

8.  Activated Notch2 potentiates CD8 lineage maturation and promotes the selective development of B1 B cells.

Authors:  Colleen M Witt; Vincent Hurez; C Scott Swindle; Yoshio Hamada; Christopher A Klug
Journal:  Mol Cell Biol       Date:  2003-12       Impact factor: 4.272

9.  Immature single-positive CD8+ thymocytes represent the transition from Notch-dependent to Notch-independent T-cell development.

Authors:  Juan Xiong; Michael A Armato; Thomas M Yankee
Journal:  Int Immunol       Date:  2010-12-09       Impact factor: 4.823

10.  The adaptor molecule signaling lymphocytic activation molecule (SLAM)-associated protein (SAP) is essential in mechanisms involving the Fyn tyrosine kinase for induction and progression of collagen-induced arthritis.

Authors:  Ming-Chao Zhong; André Veillette
Journal:  J Biol Chem       Date:  2013-09-17       Impact factor: 5.157
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