Literature DB >> 11223641

Peroxynitrite-mediated mitochondrial dysfunction.

J Boczkowski1, C L Lisdero, S Lanone, M C Carreras, M Aubier, J J Poderoso.   

Abstract

Peroxynitrite anion (ONOO(-)) is a potent biological oxidant produced by the near diffusion-limited reaction of superoxide and nitric oxide. Peroxynitrite has been implicated in diverse forms of free radical-induced tissue injury. Experimental evidence showed that exogenous and endogenous peroxynitrite causes alterations of the structure and function of mitochondrial proteins, leading to mitochondrial dysfunction and cellular or organ injury. These data are discussed along with its physiopathological implications. Copyright 2001 S. Karger AG, Basel

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Year:  2001        PMID： 11223641     DOI： 10.1159/000046876

Source DB:  PubMed          Journal:  Biol Signals Recept        ISSN： 1422-4933


  12 in total

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