Treatment concepts for premature ovarian failure.

Treatment concepts for premature ovarian failure concern restoration, preservation, and substitution of ovarian function. To date, there is no effective treatment to restore ovarian function. Preservation of ovarian function using cryopreservation and auto- or xenotransplantation will be possible in the near future. Regulation of the dynamics of the oocyte pool through GDF9 or AMH is not envisaged in the near future. Developments in estrogen receptor research may change treatment concepts in hormone replacement therapy.