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Literature DB >> 11223081

Occurrence of tetrodotoxin in the skin of a rhacophoridid frog Polypedates sp. from Bangladesh.

M B Tanu¹, Y Mahmud, K Tsuruda, O Arakawa, T Noguchi.

Abstract

Twenty-three specimens of a tree-frog Polypedates sp. were collected from two locations (Mymensingh and Barisal) of Bangladesh in 1999, and assayed for their toxicity scores and toxin principle. Among the tissues, only the skin of the Mymensingh specimens was found to be toxic in mouse test, with the toxicity scores of 31-923MU/g. The toxin isolated from the skin was analyzed by high-performance liquid chromatography, electrospray ionization-time of flight mass spectrometry and proton nuclear magnetic resonance, and characterized as tetrodotoxin, a toxin principle.

Entities: Chemical Disease Species

Mesh：

Substances：
Tetrodotoxin

Year: 2001 PMID： 11223081 DOI： 10.1016/s0041-0101(00)00231-2

Source DB: PubMed Journal: Toxicon ISSN： 0041-0101 Impact factor: 3.033

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Cited

9 in total

1. Constraint shapes convergence in tetrodotoxin-resistant sodium channels of snakes.

Authors: Chris R Feldman; Edmund D Brodie; Edmund D Brodie; Michael E Pfrender
Journal: Proc Natl Acad Sci U S A Date: 2012-03-05 Impact factor: 11.205

2. The structure of zetekitoxin AB, a saxitoxin analog from the Panamanian golden frog Atelopus zeteki: a potent sodium-channel blocker.

Authors: Mari Yotsu-Yamashita; Yong H Kim; Samuel C Dudley; Gaurav Choudhary; Arnold Pfahnl; Yasukatsu Oshima; John W Daly
Journal: Proc Natl Acad Sci U S A Date: 2004-03-22 Impact factor: 11.205

Occurrence of tetrodotoxin in the skin of a rhacophoridid frog Polypedates sp. from Bangladesh.

1. Constraint shapes convergence in tetrodotoxin-resistant sodium channels of snakes.

2. The structure of zetekitoxin AB, a saxitoxin analog from the Panamanian golden frog Atelopus zeteki: a potent sodium-channel blocker.

Review 3. The chemical and evolutionary ecology of tetrodotoxin (TTX) toxicity in terrestrial vertebrates.

4. Toxin-resistant sodium channels: parallel adaptive evolution across a complete gene family.

Review 5. Tetrodotoxin: chemistry, toxicity, source, distribution and detection.

6. The skin microbiome facilitates adaptive tetrodotoxin production in poisonous newts.

Review 7. A review of chemical defense in harlequin toads (Bufonidae: Atelopus).

Review 8. An Overview of the Anatomical Distribution of Tetrodotoxin in Animals.

Review 9. Tetrodotoxin--distribution and accumulation in aquatic organisms, and cases of human intoxication.