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Literature DB >> 11222725

Expression of human MxA protein in mosquito cells interferes with LaCrosse virus replication.

T A Miura¹, J O Carlson, B J Beaty, R A Bowen, K E Olson.

Abstract

Human MxA protein inhibits LaCrosse virus (LAC virus; family Bunyaviridae) replication in vertebrate cells and MxA-transgenic mice. LAC virus is transmitted to humans by Aedes triseriatus mosquitoes. In this report, we have shown that transfected mosquito cells expressing the human MxA cDNA are resistant to LAC virus but permissive for Sindbis virus (family Togaviridae) infection.

Entities: Gene Species

Mesh：

Substances：

Year: 2001 PMID： 11222725 PMCID： PMC115926 DOI： 10.1128/JVI.75.6.3001-3003.2001

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

15 in total

1. Inhibition of vesicular stomatitis virus mRNA synthesis by human MxA protein.

Authors: P Staeheli; J Pavlovic
Journal: J Virol Date: 1991-08 Impact factor: 5.103

Review 2. Mx transgenic mice--animal models of health.

Authors: H Arnheiter; M Frese; R Kambadur; E Meier; O Haller
Journal: Curr Top Microbiol Immunol Date: 1996 Impact factor: 4.291

3. Human MxA protein protects mice lacking a functional alpha/beta interferon system against La crosse virus and other lethal viral infections.

Authors: H P Hefti; M Frese; H Landis; C Di Paolo; A Aguzzi; O Haller; J Pavlovic
Journal: J Virol Date: 1999-08 Impact factor: 5.103

4. Human MxA protein confers resistance to Semliki Forest virus and inhibits the amplification of a Semliki Forest virus-based replicon in the absence of viral structural proteins.

Authors: H Landis; A Simon-Jödicke; A Klöti; C Di Paolo; J J Schnorr; S Schneider-Schaulies; H P Hefti; J Pavlovic
Journal: J Virol Date: 1998-02 Impact factor: 5.103

Expression of human MxA protein in mosquito cells interferes with LaCrosse virus replication.

1. Inhibition of vesicular stomatitis virus mRNA synthesis by human MxA protein.

Review 2. Mx transgenic mice--animal models of health.

3. Human MxA protein protects mice lacking a functional alpha/beta interferon system against La crosse virus and other lethal viral infections.

4. Human MxA protein confers resistance to Semliki Forest virus and inhibits the amplification of a Semliki Forest virus-based replicon in the absence of viral structural proteins.

5. Resistance to influenza virus and vesicular stomatitis virus conferred by expression of human MxA protein.

6. Effect of La Crosse virus infection on overwintering of Aedes triseriatus.

7. Human and mouse Mx proteins inhibit different steps of the influenza virus multiplication cycle.

8. Inhibition of influenza viral mRNA synthesis in cells expressing the interferon-induced Mx gene product.

9. Inhibition of bunyaviruses, phleboviruses, and hantaviruses by human MxA protein.

10. Vesicular stomatitis virus transcription inhibited by purified MxA protein.

1. Antivirally active MxA protein sequesters La Crosse virus nucleocapsid protein into perinuclear complexes.

Review 2. Innate immune response to La Crosse virus infection.

3. Human MxA protein inhibits the replication of Crimean-Congo hemorrhagic fever virus.

Review 4. Host Cell Restriction Factors of Bunyaviruses and Viral Countermeasures.

5. Bunyaviruses and the type I interferon system.