Literature DB >> 11222614

Novel lysophospholipase A secreted by Legionella pneumophila.

A Flieger1, S Gong, M Faigle, S Stevanovic, N P Cianciotto, B Neumeister.   

Abstract

We show that Legionella pneumophila possesses lysophospholipase A activity, which releases fatty acids from lysophosphatidylcholine. The NH2-terminal sequence of the enzyme contained FGDSLS, corresponding to a catalytic domain in a recently described group of lipolytic enzymes. Culture supernatants of a L. pneumophila pilD mutant lost the ability to cleave lysophosphatidylcholine.

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Year:  2001        PMID： 11222614      PMCID： PMC95111          DOI： 10.1128/JB.183.6.2121-2124.2001

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  30 in total

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Journal:  Microbes Infect       Date:  1999-11       Impact factor: 2.700

2.  Legionella pneumophila zinc metalloprotease is structurally and functionally homologous to Pseudomonas aeruginosa elastase.

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Journal:  J Bacteriol       Date:  1990-05       Impact factor: 3.490

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Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

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Journal:  Exp Mol Pathol       Date:  1977-08       Impact factor: 3.362

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Authors:  H U Weltzien
Journal:  Biochim Biophys Acta       Date:  1979-08-20

6.  Phospholipase A secreted by Legionella pneumophila destroys alveolar surfactant phospholipids.

Authors:  A Flieger; S Gongab; M Faigle; H A Mayer; U Kehrer; J Mussotter; P Bartmann; B Neumeister
Journal:  FEMS Microbiol Lett       Date:  2000-07-15       Impact factor: 2.742

7.  Cloning and expression of Legionella pneumophila antigens in Escherichia coli.

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Journal:  Infect Immun       Date:  1984-05       Impact factor: 3.441

8.  Injurious effects of lysophosphatidylcholine on barrier properties of alveolar epithelium.

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Journal:  J Appl Physiol (1985)       Date:  1987-11

9.  Lysophosphatidylcholine increases airway and capillary permeability in the isolated perfused rat lung.

Authors:  M Lindahl; A R Hede; C Tagesson
Journal:  Exp Lung Res       Date:  1986       Impact factor: 2.459

10.  Nucleotide sequence of the Azospirillum brasilense Sp7 glutamine synthetase structural gene.

Authors:  H Bozouklian; C Elmerich
Journal:  Biochimie       Date:  1986 Oct-Nov       Impact factor: 4.079
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  23 in total

1.  icmT is essential for pore formation-mediated egress of Legionella pneumophila from mammalian and protozoan cells.

Authors:  Maelle Molmeret; O A Terry Alli; Steven Zink; Antje Flieger; Nicholas P Cianciotto; Yousef Abu Kwaik
Journal:  Infect Immun       Date:  2002-01       Impact factor: 3.441

2.  The Legionella pneumophila tatB gene facilitates secretion of phospholipase C, growth under iron-limiting conditions, and intracellular infection.

Authors:  Ombeline Rossier; Nicholas P Cianciotto
Journal:  Infect Immun       Date:  2005-04       Impact factor: 3.441

3.  The global regulatory proteins LetA and RpoS control phospholipase A, lysophospholipase A, acyltransferase, and other hydrolytic activities of Legionella pneumophila JR32.

Authors:  Markus Broich; Kerstin Rydzewski; Tamara L McNealy; Reinhard Marre; Antje Flieger
Journal:  J Bacteriol       Date:  2006-02       Impact factor: 3.490

4.  Rapid escape of the dot/icm mutants of Legionella pneumophila into the cytosol of mammalian and protozoan cells.

Authors:  Maëlle Molmeret; Marina Santic'; Rexford Asare; Reynold A Carabeo; Yousef Abu Kwaik
Journal:  Infect Immun       Date:  2007-04-16       Impact factor: 3.441

5.  Importance of type II secretion for survival of Legionella pneumophila in tap water and in amoebae at low temperatures.

Authors:  Maria A Söderberg; Jenny Dao; Shawn R Starkenburg; Nicholas P Cianciotto
Journal:  Appl Environ Microbiol       Date:  2008-07-11       Impact factor: 4.792

6.  The phospholipase A effector PlaA from Legionella pneumophila: expression, purification and crystallization.

Authors:  Xiaoyan Qu; Xiaowen Song; Nannan Zhang; Jinming Ma; Honghua Ge
Journal:  Acta Crystallogr F Struct Biol Commun       Date:  2020-03-02       Impact factor: 1.056

7.  Legionella pneumophila type II secretome reveals unique exoproteins and a chitinase that promotes bacterial persistence in the lung.

Authors:  Sruti DebRoy; Jenny Dao; Maria Söderberg; Ombeline Rossier; Nicholas P Cianciotto
Journal:  Proc Natl Acad Sci U S A       Date:  2006-12-05       Impact factor: 11.205

8.  Type II protein secretion is a subset of the PilD-dependent processes that facilitate intracellular infection by Legionella pneumophila.

Authors:  O Rossier; N P Cianciotto
Journal:  Infect Immun       Date:  2001-04       Impact factor: 3.441

9.  Cloning and characterization of the gene encoding the major cell-associated phospholipase A of Legionella pneumophila, plaB, exhibiting hemolytic activity.

Authors:  Antje Flieger; Kerstin Rydzewski; Sangeeta Banerji; Markus Broich; Klaus Heuner
Journal:  Infect Immun       Date:  2004-05       Impact factor: 3.441

10.  The type II protein secretion system of Legionella pneumophila promotes growth at low temperatures.

Authors:  Maria A Söderberg; Ombeline Rossier; Nicholas P Cianciotto
Journal:  J Bacteriol       Date:  2004-06       Impact factor: 3.490
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