Literature DB >> 11221875

Interleukin-18 (IL-18) synergizes with IL-2 to enhance cytotoxicity, interferon-gamma production, and expansion of natural killer cells.

Y I Son1, R M Dallal, R B Mailliard, S Egawa, Z L Jonak, M T Lotze.   

Abstract

We investigated the in vitro effects of combining interleukin-18 (IL-18) and IL-2 on human lymphocytes. The combined use of these two cytokines synergistically enhanced the proliferation, cytolytic activity, and interferon-gamma production of peripheral blood mononuclear cells. Phenotypic analysis revealed a preferential expansion of CD56+CD3- cells and an up-regulation of IL-2 receptor-alpha expression on natural killer cells. Isolated natural killer cells showed a substantial increase in proliferation and cytotoxicity compared with CD4+ and CD8+ T cells. The combined use of IL-18 and IL-2 should be considered a viable strategy to induce an antitumor response in vivo.

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Year:  2001        PMID： 11221875

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  27 in total

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Journal:  J Virol       Date:  2010-09-29       Impact factor: 5.103

2.  The natural product phyllanthusmin C enhances IFN-γ production by human NK cells through upregulation of TLR-mediated NF-κB signaling.

Authors:  Youcai Deng; Jianhong Chu; Yulin Ren; Zhijin Fan; Xiaotian Ji; Bethany Mundy-Bosse; Shunzong Yuan; Tiffany Hughes; Jianying Zhang; Baljash Cheema; Andrew T Camardo; Yong Xia; Lai-Chu Wu; Li-Shu Wang; Xiaoming He; A Douglas Kinghorn; Xiaohui Li; Michael A Caligiuri; Jianhua Yu
Journal:  J Immunol       Date:  2014-08-13       Impact factor: 5.422

3.  IL-18 Drives ILC3 Proliferation and Promotes IL-22 Production via NF-κB.

Authors:  Aaron R Victor; Ansel P Nalin; Wenjuan Dong; Susan McClory; Min Wei; Charlene Mao; Raleigh D Kladney; Youssef Youssef; Wing Keung Chan; Edward L Briercheck; Tiffany Hughes; Steven D Scoville; Jason R Pitarresi; Charlie Chen; Sarah Manz; Lai-Chu Wu; Jianying Zhang; Michael C Ostrowski; Aharon G Freud; Gustavo W Leone; Michael A Caligiuri; Jianhua Yu
Journal:  J Immunol       Date:  2017-08-25       Impact factor: 5.422

4.  Interleukin-18 up-regulates amino acid transporters and facilitates amino acid-induced mTORC1 activation in natural killer cells.

Authors:  Saeedah Musaed Almutairi; Alaa Kassim Ali; William He; Doo-Seok Yang; Peyman Ghorbani; Lisheng Wang; Morgan D Fullerton; Seung-Hwan Lee
Journal:  J Biol Chem       Date:  2019-01-29       Impact factor: 5.157

Review 5.  Immunopathogenesis and therapy of cutaneous T cell lymphoma.

Authors:  Ellen J Kim; Stephen Hess; Stephen K Richardson; Sara Newton; Louise C Showe; Bernice M Benoit; Ravi Ubriani; Carmela C Vittorio; Jacqueline M Junkins-Hopkins; Maria Wysocka; Alain H Rook
Journal:  J Clin Invest       Date:  2005-04       Impact factor: 14.808

6.  IL-2 and IL-18 attenuation of airway hyperresponsiveness requires STAT4, IFN-gamma, and natural killer cells.

Authors:  Shigeki Matsubara; Katsuyuki Takeda; Taku Kodama; Anthony Joetham; Nobuaki Miyahara; Toshiyuki Koya; Christina H Swasey; Masakazu Okamoto; Azzeddine Dakhama; Erwin W Gelfand
Journal:  Am J Respir Cell Mol Biol       Date:  2006-10-12       Impact factor: 6.914

7.  Immune reconstitution of acquired immune deficiency syndrome.

Authors:  Jie Wang; Hong-sheng Lin; Meng-yu Liu; Yong Li
Journal:  Chin J Integr Med       Date:  2010-11-26       Impact factor: 1.978

8.  Human IL18-IL2 fusion protein as a potential antitumor reagent by enhancing NK cell cytotoxicity and IFN-γ production.

Authors:  Guangying Du; Liang Ye; Guoying Zhang; Qiuju Dong; Kun Liu; Jingwei Tian
Journal:  J Cancer Res Clin Oncol       Date:  2012-06-15       Impact factor: 4.553

9.  Inflammasomes Coordinate Pyroptosis and Natural Killer Cell Cytotoxicity to Clear Infection by a Ubiquitous Environmental Bacterium.

Authors:  Vivien I Maltez; Alan L Tubbs; Kevin D Cook; Youssef Aachoui; E Liana Falcone; Steven M Holland; Jason K Whitmire; Edward A Miao
Journal:  Immunity       Date:  2015-11-10       Impact factor: 31.745

Review 10.  Application of tissue-specific NK and NKT cell activity for tumor immunotherapy.

Authors:  Jeff J Subleski; Robert H Wiltrout; Jonathan M Weiss
Journal:  J Autoimmun       Date:  2009-08-13       Impact factor: 7.094
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