Literature DB >> 11221078

[Efficacy of bacteriophages in complex treatment of patients with burn wounds].

E B Lazareva1, S V Smirnov, V B Khvatov, T G Spiridonova, E E Bitkova, O S Darbeeva, L M Maĭskaia, R L Parfeniuk, D D Men'shikov.   

Abstract

Results of clinical and laboratory evaluation of the treatment with pyobacteriophage in tablets of the patients with burn wounds are presented. It was shown that phagotherapy provided more rapid cure of pyoseptic complications, temperature normalization, wounds purification and lower lethality Bacteriological analysis of wound secretions revealed that after the treatment staphylococci and streptococci were cultured 2 times rarely, Proteus spp. Were isolated 1.5 times rarely, E. coli was not isolated. The amount of positive haemocultures also diminished. Investigation of immunologic status demonstrated statistically significant normalization of immunity on cell level. Phagocytosis level didn't change while in control group (without bacteriophage use) it became lower. Antibody level enhanced but less extensively than in control group. The results of trial demonstrates positive effect of phagotherapy use at the patients with burns.

Entities:  

Mesh:

Substances:

Year:  2001        PMID: 11221078

Source DB:  PubMed          Journal:  Antibiot Khimioter        ISSN: 0235-2990


  9 in total

Review 1.  Bacteriophage therapy against Enterobacteriaceae.

Authors:  Youqiang Xu; Yong Liu; Yang Liu; Jiangsen Pei; Su Yao; Chi Cheng
Journal:  Virol Sin       Date:  2015-02-03       Impact factor: 4.327

Review 2.  Nanomedicine and advanced technologies for burns: Preventing infection and facilitating wound healing.

Authors:  Mirza Ali Mofazzal Jahromi; Parham Sahandi Zangabad; Seyed Masoud Moosavi Basri; Keyvan Sahandi Zangabad; Ameneh Ghamarypour; Amir R Aref; Mahdi Karimi; Michael R Hamblin
Journal:  Adv Drug Deliv Rev       Date:  2017-08-04       Impact factor: 15.470

3.  Phage treatment of human infections.

Authors:  Stephen T Abedon; Sarah J Kuhl; Bob G Blasdel; Elizabeth Martin Kutter
Journal:  Bacteriophage       Date:  2011-03

Review 4.  The Safety and Efficacy of Phage Therapy for Superficial Bacterial Infections: A Systematic Review.

Authors:  Angharad Steele; Helen J Stacey; Steven de Soir; Joshua D Jones
Journal:  Antibiotics (Basel)       Date:  2020-10-29

5.  Co-therapy using lytic bacteriophage and linezolid: effective treatment in eliminating methicillin resistant Staphylococcus aureus (MRSA) from diabetic foot infections.

Authors:  Sanjay Chhibber; Tarsem Kaur
Journal:  PLoS One       Date:  2013-02-13       Impact factor: 3.240

Review 6.  Applications of Bacteriophages in the Treatment of Localized Infections in Humans.

Authors:  Vera V Morozova; Valentin V Vlassov; Nina V Tikunova
Journal:  Front Microbiol       Date:  2018-08-02       Impact factor: 5.640

Review 7.  Application of Phagotherapy in the Treatment of Burn Patients (Review).

Authors:  А E Leontyev; I V Pavlenko; О V Kovalishena; N V Saperkin; А А Tulupov; V V Beschastnov
Journal:  Sovrem Tekhnologii Med       Date:  2020-06-28

Review 8.  A genetic approach to the development of new therapeutic phages to fight pseudomonas aeruginosa in wound infections.

Authors:  Victor Krylov; Olga Shaburova; Sergey Krylov; Elena Pleteneva
Journal:  Viruses       Date:  2012-12-21       Impact factor: 5.048

9.  Perspectives of Phage Therapy in Non-bacterial Infections.

Authors:  Andrzej Górski; Paul L Bollyky; Maciej Przybylski; Jan Borysowski; Ryszard Międzybrodzki; Ewa Jończyk-Matysiak; Beata Weber-Dąbrowska
Journal:  Front Microbiol       Date:  2019-01-09       Impact factor: 5.640

  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.