Literature DB >> 11220748

Propofol in subanesthetic doses terminates status epilepticus in a rodent model.

M Holtkamp1, X Tong, M C Walker.   

Abstract

Status epilepticus is commonly refractory to first-line therapy, and thus better treatments are needed. We have investigated an experimental model of drug-resistant self-sustaining status epilepticus (SSSE) induced by 2 hours of perforant path stimulation. Propofol in subanesthetic doses administered shortly after the end of stimulation and also after a further 3 hours of SSSE terminated the SSSE without recurrence. This finding calls for a trial of propofol in refractory status epilepticus and also raises the possibility of using it as first-line therapy.

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Year:  2001        PMID： 11220748

Source DB:  PubMed          Journal:  Ann Neurol        ISSN： 0364-5134            Impact factor:   10.422


  7 in total

1.  The management of refractory generalised convulsive and complex partial status epilepticus in three European countries: a survey among epileptologists and critical care neurologists.

Authors:  M Holtkamp; F Masuhr; L Harms; K M Einhäupl; H Meierkord; K Buchheim
Journal:  J Neurol Neurosurg Psychiatry       Date:  2003-08       Impact factor: 10.154

Review 2.  Pharmacotherapy for Refractory and Super-Refractory Status Epilepticus in Adults.

Authors:  Martin Holtkamp
Journal:  Drugs       Date:  2018-03       Impact factor: 9.546

Review 3.  [Refractory status epilepticus: diagnosis, therapy, course, and prognosis].

Authors:  F Bösebeck; G Möddel; K Anneken; M Fischera; S Evers; E B Ringelstein; C Kellinghaus
Journal:  Nervenarzt       Date:  2006-10       Impact factor: 1.214

4.  Early EEG monitoring for detecting postanoxic status epilepticus during therapeutic hypothermia: a pilot study.

Authors:  Stéphane Legriel; Fabrice Bruneel; Haouaria Sediri; Julia Hilly; Nathalie Abbosh; Matthieu Henry Lagarrigue; Gilles Troche; Pierre Guezennec; Fernando Pico; Jean Pierre Bedos
Journal:  Neurocrit Care       Date:  2009-12       Impact factor: 3.210

Review 5.  First-line management of canine status epilepticus at home and in hospital-opportunities and limitations of the various administration routes of benzodiazepines.

Authors:  Marios Charalambous; Holger A Volk; Luc Van Ham; Sofie F M Bhatti
Journal:  BMC Vet Res       Date:  2021-03-04       Impact factor: 2.741

6.  Seizure control by ketogenic diet-associated medium chain fatty acids.

Authors:  Pishan Chang; Nicole Terbach; Nick Plant; Philip E Chen; Matthew C Walker; Robin S B Williams
Journal:  Neuropharmacology       Date:  2012-11-20       Impact factor: 5.250

7.  Propofol infusion syndrome in refractory status epilepticus.

Authors:  Woo Sub Hwang; Hye Min Gwak; Dae-Won Seo
Journal:  J Epilepsy Res       Date:  2013-06-30
  7 in total

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