N Magné1, C Foa, J N Bruneton, P Y Marcy. 1. Service d'oncologie médicale, centre Antoine-Lacassagne, 33, avenue de Valombrose, 06189 Nice, France. magne@unice.fr
Abstract
INTRODUCTION: Multifocal osteonecrosis has a wide variety of etiologies, but in the cancer patient several risk factors could have a synergic effect (chemotherapy, radiotherapy, corticosteroid, metabolism disorder). EXEGESIS: A patient with testicular seminoma receiving cisplatin-based chemotherapy and short-term corticosteroid developed multifocal osteonecrosis. Early diagnosis of osteonecrosis is important to prevent orthopedic complications. CONCLUSION: Cisplatin could represent one of the possible etiologies of multifocal osteonecrosis. Magnetic resonance imaging has a high sensitivity and specificity in the diagnosis of osteonecrosis and should be used when this condition is suspected.
INTRODUCTION: Multifocal osteonecrosis has a wide variety of etiologies, but in the cancerpatient several risk factors could have a synergic effect (chemotherapy, radiotherapy, corticosteroid, metabolism disorder). EXEGESIS: A patient with testicular seminoma receiving cisplatin-based chemotherapy and short-term corticosteroid developed multifocal osteonecrosis. Early diagnosis of osteonecrosis is important to prevent orthopedic complications. CONCLUSION:Cisplatin could represent one of the possible etiologies of multifocal osteonecrosis. Magnetic resonance imaging has a high sensitivity and specificity in the diagnosis of osteonecrosis and should be used when this condition is suspected.