| Literature DB >> 11217105 |
H Eto1, Y Kaneko, S Takeda, M Tokizawa, S Sato, K Yoshida, S Namiki, M Ogawa, K Maebashi, K Ishida, M Matsumoto, T Asaoka.
Abstract
New 1,2,4-triazoles (2) having a difluoro(substituted sulfonyl)methyl moiety were designed and synthesized via alpha,alpha-difluoro-alpha-(substituted thio)acetophenones (3). Compounds (2) showed potent antifungal activities against C. albicans, C. krusei, A. flavus and A. fumigatus in vitro and against C. albicans in vivo for oral and i.v. administrations. Especially, (-)-2a, (-)-2b and (-)-2d showed potent antifungal activities.Entities:
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Year: 2001 PMID： 11217105 DOI： 10.1248/cpb.49.173
Source DB: PubMed Journal: Chem Pharm Bull (Tokyo) ISSN： 0009-2363 Impact factor: 1.645