Literature DB >> 11216478

Anticancer activity of hydrophobic peptides from soy proteins.

S E Kim1, H H Kim, J Y Kim, Y I Kang, H J Woo, H J Lee.   

Abstract

An anticancer peptide from soy protein was purified and isolated. Defatted soy protein was hydrolyzed with thermoase and hydrophobic peptides were extracted with ethanol. The peptide extract was fractionated by XAD-2 hydrophobic, gel filtration chromatography, and different C18 HPLCs. Anticancer activity of each fraction was assayed by measuring in vitro cytotoxicity on P388D1, a mouse monocyte macrophage cell line. IC50 value of a peptide fraction from Sephadex G-25 chromatography was 0.16 mg/ml. This peptide fraction at 1 mg/ml significantly affected cell cycle progression by arresting P388D1 at G2/M phases. Finally purified peptide from analytical C18 HPLC was nonapeptide of which molecular weight was 1157 Da and the sequence was X-Met-Leu-Pro-Ser-Tye-Ser-Pro-Tyr.

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Year:  2000        PMID： 11216478     DOI： 10.1002/biof.5520120124

Source DB:  PubMed          Journal:  Biofactors        ISSN： 0951-6433            Impact factor:   6.113


  13 in total

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2.  Iron binding capacity of dephytinised soy protein isolate hydrolysate as influenced by the degree of hydrolysis and enzyme type.

Authors:  Mo-Nan Zhang; Guang-Rong Huang; Jia-Xin Jiang
Journal:  J Food Sci Technol       Date:  2011-11-15       Impact factor: 2.701

3.  Potential antitumor properties of a protein isolate obtained from the seeds of Amaranthus mantegazzianus.

Authors:  Daniel Alejandro Barrio; María Cristina Añón
Journal:  Eur J Nutr       Date:  2009-08-22       Impact factor: 5.614

4.  Isoflavone-deprived soy peptide suppresses mammary tumorigenesis by inducing apoptosis.

Authors:  Kyoungsook Park; Kyusam Choi; Hyemee Kim; Kwangbae Kim; Mi Hee Lee; Je Ho Lee; Jean Chinock Kim Rim
Journal:  Exp Mol Med       Date:  2009-06-30       Impact factor: 8.718

5.  Bioactive peptide of Cicer arietinum L. induces apoptosis in human endometrial cancer via DNA fragmentation and cell cycle arrest.

Authors:  Neha Gupta; Sameer Suresh Bhagyawant
Journal:  3 Biotech       Date:  2021-01-12       Impact factor: 2.406

6.  Chemopreventive and Antioxidant Effect of Polyphenol Free Spirulina maxima and Its Hydrolyzed Protein Content: Investigation on Azoxymethane Treated Mice.

Authors:  Nikte Y Martínez-Palma; Gloria Dávila-Ortiz; Cristian Jiménez-Martínez; Eduardo Madrigal-Bujaidar; Isela Álvarez-González
Journal:  Pharmacogn Mag       Date:  2017-07-11       Impact factor: 1.085

7.  Food-Derived High Arginine Peptides Promote Spermatogenesis Recovery in Busulfan Treated Mice.

Authors:  Wenwen Liu; Lingfeng Zhang; Anning Gao; Muhammad Babar Khawar; Fengyi Gao; Wei Li
Journal:  Front Cell Dev Biol       Date:  2021-12-21

8.  Enzymatic hydrolysis and simultaneous saccharification and fermentation of soybean processing intermediates for the production of ethanol and concentration of protein and lipids.

Authors:  Craig C Long; William Gibbons
Journal:  ISRN Microbiol       Date:  2012-10-17

Review 9.  Soybean Bioactive Peptides and Their Functional Properties.

Authors:  Cynthia Chatterjee; Stephen Gleddie; Chao-Wu Xiao
Journal:  Nutrients       Date:  2018-09-01       Impact factor: 5.717

10.  Casein Oligochitosan-Glycation by Transglutaminase Enhances the Anti-Inflammatory Potential of Casein Hydrolysates to the Lipopolysaccharide-Stimulated IEC-6 Cells.

Authors:  Na Chen; Li Wang; Qiang Zhang; Xin-Huai Zhao; Jia Shi
Journal:  Nutrients       Date:  2022-02-06       Impact factor: 5.717
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