Literature DB >> 11215523

Lysophosphatidic acid: receptors, signaling and survival.

J T Swarthout1, H W Walling.   

Abstract

Though the mitogenic activity of lysophosphatidic acid (LPA) has been well established through classical studies, its mechanism of action was long obscure. Recent identification and cloning of LPA-specific receptors has led to the elucidation of the G-proteins and signaling pathways through which this molecule functions. In addition to its mitogenic properties, recent reports have suggested that LPA may also promote cell survival. This review will summarize the current literature regarding LPA signaling and its role as an antiapoptotic factor.

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Year:  2000        PMID： 11215523     DOI： 10.1007/PL00000678

Source DB:  PubMed          Journal:  Cell Mol Life Sci        ISSN： 1420-682X            Impact factor:   9.261


  17 in total

1.  Pleiotropic phenotype of a genomic knock-in of an RGS-insensitive G184S Gnai2 allele.

Authors:  Xinyan Huang; Ying Fu; Raelene A Charbeneau; Thomas L Saunders; Douglas K Taylor; Kurt D Hankenson; Mark W Russell; Louis G D'Alecy; Richard R Neubig
Journal:  Mol Cell Biol       Date:  2006-09       Impact factor: 4.272

2.  Identification of X-linked genes required for migration and programmed cell death of Drosophila melanogaster germ cells.

Authors:  Clark R Coffman; Rachel C Strohm; Fredrick D Oakley; Yukiko Yamada; Danielle Przychodzin; Robert E Boswell
Journal:  Genetics       Date:  2002-09       Impact factor: 4.562

3.  Expression and function of calcium-activated potassium channels in human glioma cells.

Authors:  Amy K Weaver; Valerie C Bomben; Harald Sontheimer
Journal:  Glia       Date:  2006-08-15       Impact factor: 7.452

Review 4.  Mechanisms of neuronal membrane sealing following mechanical trauma.

Authors:  Benjamin K Hendricks; Riyi Shi
Journal:  Neurosci Bull       Date:  2014-07-04       Impact factor: 5.203

5.  Phosphatidic acid mediates activation of mTORC1 through the ERK signaling pathway.

Authors:  Jeremiah N Winter; Todd E Fox; Mark Kester; Leonard S Jefferson; Scot R Kimball
Journal:  Am J Physiol Cell Physiol       Date:  2010-04-28       Impact factor: 4.249

6.  Quantitative phosphoproteome analysis of lysophosphatidic acid induced chemotaxis applying dual-step (18)O labeling coupled with immobilized metal-ion affinity chromatography.

Authors:  Shi-Jian Ding; Yingchun Wang; Jon M Jacobs; Wei-Jun Qian; Feng Yang; Aleksey V Tolmachev; Xiuxia Du; Wei Wang; Ronald J Moore; Matthew E Monroe; Samuel O Purvine; Katrina Waters; Tyler H Heibeck; Joshua N Adkins; David G Camp; Richard L Klemke; Richard D Smith
Journal:  J Proteome Res       Date:  2008-09-12       Impact factor: 4.466

7.  Phospholipid metabolism is required for M1 muscarinic inhibition of N-type calcium current in sympathetic neurons.

Authors:  Liwang Liu; Mandy L Roberts; Ann R Rittenhouse
Journal:  Eur Biophys J       Date:  2004-03-05       Impact factor: 1.733

8.  Lysophosphatidic acid protects cancer cells from histone deacetylase (HDAC) inhibitor-induced apoptosis through activation of HDAC.

Authors:  Ganchimeg Ishdorj; Bonnie A Graham; Xiaojie Hu; Jing Chen; James B Johnston; Xianjun Fang; Spencer B Gibson
Journal:  J Biol Chem       Date:  2008-04-11       Impact factor: 5.157

9.  Albumin stimulates lysophosphatidic acid acyltransferase activity in T-lymphocyte membranes.

Authors:  Christopher A Jolly; Latha Kannan
Journal:  Lipids       Date:  2002-05       Impact factor: 1.880

10.  Receptor-mediated vascular smooth muscle migration induced by LPA involves p38 mitogen-activated protein kinase pathway activation.

Authors:  Zhi-Bin Zhou; Jian-Ping Niu; Zhi-Jun Zhang
Journal:  Int J Mol Sci       Date:  2009-07-13       Impact factor: 6.208
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